Literature DB >> 1695653

Determination of a unique and immunodominant epitope of human T cell lymphotropic virus type I.

J J Lipka1, K Bui, G R Reyes, R Moeckli, S Z Wiktor, W A Blattner, E L Murphy, G M Shaw, C V Hanson, J J Sninsky.   

Abstract

The identification and isolation of unique and immunogenic recombinant epitopes for human T cell lymphotrophic virus (HTLV) type I might allow the development of an antibody-based assay to differentiate between HTLV-I and HTLV-II infections. To test the feasibility of this approach, an HTLV-I envelope epitope was isolated by immunoscreening of a lambda gt11 recombinant HTLV-I DNA library with a human monoclonal antibody to HTLV-I. This recombinant epitope. MTA-4, when tested with sera from HTLV-I- or HTLV-II-infected individuals, was reactive with all HTLV-I and nonreactive with all HTLV-II antisera. These results indicate that MTA-4 is a unique and immunodominant epitope on HTLV-I and confirm the usefulness of human-derived monoclonal antibodies in an experimental approach to dissect the human humoral response to a viral pathogen.

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Year:  1990        PMID： 1695653     DOI： 10.1093/infdis/162.2.353

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

1.  Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.

Authors:  K G Hadlock; J Rowe; S Perkins; P Bradshaw; G Y Song; C Cheng; J Yang; R Gascon; J Halmos; S M Rehman; M S McGrath; S K Foung
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  A new and frequent human T-cell leukemia virus indeterminate Western blot pattern: epidemiological determinants and PCR results in central African inhabitants.

Authors:  Claudia Filippone; Sylviane Bassot; Edouard Betsem; Patricia Tortevoye; Micheline Guillotte; Odile Mercereau-Puijalon; Sabine Plancoulaine; Sara Calattini; Antoine Gessain
Journal:  J Clin Microbiol       Date:  2012-03-07       Impact factor: 5.948

3.  Detection and differentiation of antibodies to human T-cell lymphotropic virus types I and II by the immunofluorescence method.

Authors:  D Gallo; L M Penning; C V Hanson
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

4.  A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: expression of gp46 by the vaccinia virus/T7 polymerase system.

Authors:  J Arp; M LeVatte; J Rowe; S Perkins; E King; C Leystra-Lantz; S K Foung; G A Dekaban
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

5.  Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

Authors:  P Horal; W W Hall; B Svennerholm; J Lycke; S Jeansson; L Rymo; M H Kaplan; A Vahlne
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

6.  Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic restriction.

Authors:  M D Lairmore; A M DiGeorge; S F Conrad; A V Trevino; R B Lal; P T Kaumaya
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

7.  Synthetic peptide-based immunoassays for distinguishing between human T-cell lymphotropic virus type I and type II infections in seropositive individuals.

Authors:  R B Lal; W Heneine; D L Rudolph; W B Present; D Hofhienz; T M Hartley; R F Khabbaz; J E Kaplan
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

8.  The humoral immune response to human T-cell lymphotropic virus type 1 envelope glycoprotein gp46 is directed primarily against conformational epitopes.

Authors:  K G Hadlock; J Rowe; S K Foung
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

9.  Isolation and characterization of simian T-cell leukemia virus type II from New World monkeys.

Authors:  Y M Chen; Y J Jang; P J Kanki; Q C Yu; J J Wang; R J Montali; K P Samuel; T S Papas
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103

10.  Sensitivity and specificity of a recombinant transmembrane glycoprotein (rgp21)-spiked western immunoblot for serological confirmation of human T-cell lymphotropic virus type I and type II infections.

Authors:  R B Lal; S Brodine; J Kazura; E Mbidde-Katonga; R Yanagihara; C Roberts
Journal:  J Clin Microbiol       Date:  1992-02       Impact factor: 5.948
  10 in total

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