Literature DB >> 16954977

Modern management of laryngotracheal stenosis.

Heather C Herrington1, Stephen M Weber, Peter E Andersen.   

Abstract

OBJECTIVES: Laryngotracheal stenosis is a complex problem resulting most often from intubation, trauma,or autoimmune disease. Management options include dilation or airway reconstruction including laryngotracheoplasty (LTP), cricotracheal resection (CTR), and tracheal resection (TR). We describe our experience with management of this difficult problem. STUDY
DESIGN: Retrospective chart review of patients treated for laryngotracheal stenosis between January 1995 and July 2005 at an academic, tertiary referral center.
METHODS: A total of 127 patients were treated during the study period. Patients were followed, and hospital records were reviewed.
RESULTS: There were 38 male and 89 female patients with an average age of 55.5 years treated for laryngotracheal stenosis resulting from intubation (64), idiopathic (25) or autoimmune disease (18), radiation (9), trauma (5), prior surgery (4), and relapsing polychondritis (2). Thirty-three percent were treated for grade I stenosis, 44% grade II, 19% grade III, and 4% grade IV. Seventy percent of patients undergoing initial dilation required a subsequent procedure. LTP, CTR, or TR was performed in 43%, 48%, 71%, and 100% of patients with grade I through IV stenosis, respectively. Among 76 patients undergoing LTP, CTR, or TR, 24 (32%) required a subsequent intervention. Among 36 patients treated with primary LTP, CTR, or TR, only 10 (28%) required further therapy. Twenty-two of 35 (63%) tracheostomy-dependent patients were ultimately decannulated. Three patients died in the immediate postoperative period.
CONCLUSIONS: Patients undergoing dilation for laryngotracheal stenosis require multiple procedures. However, major reconstructive procedures are well tolerated and currently represent a viable primary treatment for laryngotracheal stenosis.

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Year:  2006        PMID: 16954977     DOI: 10.1097/01.mlg.0000228006.21941.12

Source DB:  PubMed          Journal:  Laryngoscope        ISSN: 0023-852X            Impact factor:   3.325


  29 in total

1.  Interferon-γ Treatment of Human Laryngotracheal Stenosis-Derived Fibroblasts.

Authors:  Kevin Motz; Idris Samad; Linda X Yin; Michael K Murphy; Madhavi Duvvuri; Dacheng Ding; Alexander T Hillel
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2017-11-01       Impact factor: 6.223

2.  Predicting outcome in tracheal and cricotracheal segmental resection.

Authors:  Gabriel Nakache; A Primov-Fever; E E Alon; M Wolf
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-02-25       Impact factor: 2.503

3.  Metabolic variations in normal and fibrotic human laryngotracheal-derived fibroblasts: A Warburg-like effect.

Authors:  Garret Ma; Idris Samad; Kevin Motz; Linda X Yin; Madhavi V Duvvuri; Dacheng Ding; Daryan R Namba; Jennifer H Elisseeff; Maureen R Horton; Alexander T Hillel
Journal:  Laryngoscope       Date:  2016-09-01       Impact factor: 3.325

4.  Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro.

Authors:  Daryan R Namba; Garret Ma; Idris Samad; Dacheng Ding; Vinciya Pandian; Jonathan D Powell; Maureen R Horton; Alexander T Hillel
Journal:  Otolaryngol Head Neck Surg       Date:  2015-03-09       Impact factor: 3.497

5.  Targeting metabolic abnormalities to reverse fibrosis in iatrogenic laryngotracheal stenosis.

Authors:  Michael K Murphy; Kevin M Motz; Dacheng Ding; Linda Yin; Madhavi Duvvuri; Michael Feeley; Alexander T Hillel
Journal:  Laryngoscope       Date:  2017-09-20       Impact factor: 3.325

6.  The therapy with ethosomes containing 5-fluorouracil for laryngotracheal stenosis in rabbit models.

Authors:  Xiaohui Mao; Xuefeng Cheng; Zheng Zhang; Zhaoyan Wang; Zhentao Wang
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-12-21       Impact factor: 2.503

7.  T-Helper 2 Lymphocyte Immunophenotype Is Associated With Iatrogenic Laryngotracheal Stenosis.

Authors:  Alexander T Hillel; Dacheng Ding; Idris Samad; Michael K Murphy; Kevin Motz
Journal:  Laryngoscope       Date:  2018-11-13       Impact factor: 3.325

8.  Evaluation of Dyspnea Outcomes After Endoscopic Airway Surgery for Laryngotracheal Stenosis.

Authors:  Idris Samad; Lee Akst; Selmin Karatayli-Özgürsoy; Kristine Teets; Marissa Simpson; Ashwyn Sharma; Simon R A Best; Alexander T Hillel
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2016-11-01       Impact factor: 6.223

9.  Finding balance between minimally invasive surgery and laryngotracheal resection in the management of adult laryngotracheal stenosis.

Authors:  György B Halmos; Fréderique S A M Schuiringa; Dóra Pálinkó; Tom P van der Laan; Frederik G Dikkers
Journal:  Eur Arch Otorhinolaryngol       Date:  2014-02-02       Impact factor: 2.503

10.  Health Care Costs and Cost-effectiveness in Laryngotracheal Stenosis.

Authors:  Linda X Yin; William V Padula; Shekhar Gadkaree; Kevin Motz; Sabrina Rahman; Zachary Predmore; Alexander Gelbard; Alexander T Hillel
Journal:  Otolaryngol Head Neck Surg       Date:  2018-11-27       Impact factor: 3.497

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