Literature DB >> 1695433

Influence of TMB-8 and calmidazolium on phorbol ester promoted histamine release from isolated rat mast cells.

N Grosman1, J K Nielsen.   

Abstract

The effects of TMB-8 and calmidazolium were investigated on mast cell responses believed to be mediated by protein kinase C, i.e. histamine release induced by TPA (tetradecanoyl-phorbol-acetate) in combination with sub-threshold concentrations of the ionophore A23187 and with antigen. Inhibition with both drugs was found in the same concentration range as observed earlier and could be counteracted by glucose, indicating an impaired oxidative energy production. Hence, the test drugs do not reveal protein kinase C selectivity.

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Year:  1990        PMID： 1695433     DOI： 10.1007/bf01969019

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Effect of TMB-8 on histamine release from isolated rat mast cells.

Authors:  N Grossman
Journal:  Int Arch Allergy Appl Immunol       Date:  1986

2.  Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells.

Authors:  N Grosman
Journal:  Agents Actions       Date:  1986-03

Review 3.  Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

Authors:  P M Blumberg
Journal:  Cancer Res       Date:  1988-01-01       Impact factor: 12.701

4.  Effect of divalent cations and metabolic energy on the anaphylactic histamine release from rat peritoneal mast cells.

Authors:  B Diamant; N Grosman; P Stahl Skov; S Thomle
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

Review 5.  Studies and perspectives of protein kinase C.

Authors:  Y Nishizuka
Journal:  Science       Date:  1986-07-18       Impact factor: 47.728

6.  Phospholipid-sensitive Ca2+-dependent protein kinase inhibition by R-24571, a calmodulin antagonist.

Authors:  G J Mazzei; R C Schatzman; R S Turner; W R Vogler; J F Kuo
Journal:  Biochem Pharmacol       Date:  1984-01-01       Impact factor: 5.858

7.  The influence of tetradecanoyl-phorbol-acetate (TPA) on histamine release from isolated rat mast cells.

Authors:  N Grosman; K A Nielsen
Journal:  Agents Actions       Date:  1988-06

8.  Mechanism of inhibitory action of TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] on aldosterone secretion in adrenal glomerulosa cells.

Authors:  I Kojima; K Kojima; H Rasmussen
Journal:  Biochem J       Date:  1985-11-15       Impact factor: 3.857
  8 in total
  1 in total

1.  Sphingosine inhibition and promotion of histamine release from isolated rat mast cells.

Authors:  N Grosman
Journal:  Agents Actions       Date:  1990-11
  1 in total

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