Literature DB >> 1695432

Unusual effects of the ionophore A23187 at suboptimal concentrations in mast cell histamine release.

N Grosman1, J K Nielsen.   

Abstract

Certain peculiarities are observed in connection with histamine release induced by suboptimal concentrations of the ionophore A23187. The potency of the ionophore can increase by a factor of 3 when added to the incubation medium from solutions in either DMSO or buffer without added calcium as compared with addition from standard buffer. The effect was not due to the solvent per se but may relate to physicochemical conditions facilitating the ionophore's access to cellular domains.

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Year:  1990        PMID： 1695432     DOI： 10.1007/bf01969018

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Dimethyl sulfoxide inhibits histamine release induced by various chemicals.

Authors:  L Candussio; F B Klugmann; G Decorti; S Bevilacqua; L Baldini
Journal:  Agents Actions       Date:  1987-02

2.  Characterization of the effects of phorbol esters on rat mast cell secretion.

Authors:  A S Heiman; F T Crews
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

3.  Effect of divalent cations and metabolic energy on the anaphylactic histamine release from rat peritoneal mast cells.

Authors:  B Diamant; N Grosman; P Stahl Skov; S Thomle
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

Review 4.  Pharmacologic and biochemical considerations of dimethyl sulfoxide.

Authors:  D C Wood; J Wood
Journal:  Ann N Y Acad Sci       Date:  1975-01-27       Impact factor: 5.691

5.  Equilibria between ionophore A23187 and divalent cations: stability of 1:1 complexes in solutions of 80% methanol/water.

Authors:  C J Chapman; A K Puri; R W Taylor; D R Pfeiffer
Journal:  Biochemistry       Date:  1987-08-11       Impact factor: 3.162

6.  The influence of tetradecanoyl-phorbol-acetate (TPA) on histamine release from isolated rat mast cells.

Authors:  N Grosman; K A Nielsen
Journal:  Agents Actions       Date:  1988-06

7.  Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release.

Authors:  P Moldt; W K Andersen; S B Christensen
Journal:  Agents Actions       Date:  1988-06

8.  Effects of dimethylsulfoxide (DMSO), nocodazole, and taxol on mast cell histamine secretion.

Authors:  E H Nielsen; T Johansen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1986-09

9.  Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.

Authors:  Y Katakami; K Kaibuchi; M Sawamura; Y Takai; Y Nishizuka
Journal:  Biochem Biophys Res Commun       Date:  1984-06-15       Impact factor: 3.575
  9 in total

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