Literature DB >> 16954278

Molecular differentiation of Treponema pallidum subspecies.

Arturo Centurion-Lara1, Barbara J Molini, Charmie Godornes, Eileen Sun, Karin Hevner, Wesley C Van Voorhis, Sheila A Lukehart.   

Abstract

Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test. In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme.

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Year:  2006        PMID： 16954278      PMCID： PMC1594706          DOI： 10.1128/JCM.00784-06

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  33 in total

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10.  Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.

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Journal:  J Immunol       Date:  1980-01       Impact factor: 5.422
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  28 in total

Review 1.  The endemic treponematoses.

Authors:  Lorenzo Giacani; Sheila A Lukehart
Journal:  Clin Microbiol Rev       Date:  2014-01       Impact factor: 26.132

Review 2.  The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms.

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3.  Current trends in donor testing to detect syphilis infection.

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4.  Laboratory-confirmed case of yaws in a 10-year-old boy from the Republic of the Congo.

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5.  When is syphilis not syphilis? Or is it?

Authors:  Sheila A Lukehart; Lorenzo Giacani
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Review 6.  Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.

Authors:  David Smajs; Steven J Norris; George M Weinstock
Journal:  Infect Genet Evol       Date:  2011-12-15       Impact factor: 3.342

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8.  Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods.

Authors:  Kai-Hua Chi; Damien Danavall; Fasihah Taleo; Allan Pillay; Tun Ye; Eli Nachamkin; Jacob L Kool; David Fegan; Kingsley Asiedu; Lasse S Vestergaard; Ronald C Ballard; Cheng-Yen Chen
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9.  Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method.

Authors:  Sibylle Gerstl; Gédeon Kiwila; Mehul Dhorda; Sylvaine Lonlas; Mark Myatt; Benoît Kebela Ilunga; Denis Lemasson; Elisabeth Szumilin; Philippe J Guerin; Laurent Ferradini
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Review 10.  Challenges and key research questions for yaws eradication.

Authors:  Michael Marks; Oriol Mitjà; Lasse S Vestergaard; Allan Pillay; Sascha Knauf; Cheng-Yen Chen; Quique Bassat; Diana L Martin; David Fegan; Fasihah Taleo; Jacob Kool; Sheila Lukehart; Paul M Emerson; Anthony W Solomon; Tun Ye; Ronald C Ballard; David C W Mabey; Kingsley B Asiedu
Journal:  Lancet Infect Dis       Date:  2015-09-08       Impact factor: 25.071
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