Literature DB >> 1695384

15-Hydroxyeicosatetraenoic acid stimulates migration of human retinal microvessel endothelium in vitro and neovascularization in vivo.

J E Graeber1, B M Glaser, B N Setty, J A Jerdan, R W Walenga, M J Stuart.   

Abstract

We evaluated 15-hydroxyeicosatetraenoic acid (15-HETE), a major arachidonic acid product of vascular endothelium and leukocytes, for its effect on neovascularization. In a modified Boyden chamber assay, 15-HETE (10-7 M) stimulated human retinal microvessel endothelial cell migration by 42 +/- 10% (mean +/- S.E.M., p less than 0.01). 12-HETE, a major arachidonic acid metabolite of platelets, had no such effect. Further studies in the rabbit corneal pocket assay revealed that 15-HETE stimulated neovascularization in vivo. Concentrations at which the in vivo effects were observed are within the range generated by several cell types and are achievable in human serum. 15-HETE stimulation of human endothelial cell migration in vitro and neovascularization in vivo suggests that it may play a role in vasoproliferative disorders.

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Year:  1990        PMID： 1695384     DOI： 10.1016/0090-6980(90)90026-r

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  8 in total

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7.  The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8.

Authors:  Sergey Y Cheranov; Dong Wang; Venkatesh Kundumani-Sridharan; Manjula Karpurapu; Qiuhua Zhang; Koteswara R Chava; Gadiparthi N Rao
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  8 in total

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