Mirta Knoepfelmacher1, Debora L S Danilovic, Rubia H R Rosa Nasser, Berenice B Mendonça. 1. Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. mirta@uol.com.br
Abstract
OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas. DESIGN: Case report. SETTING: Outpatient practice. PATIENT(S): Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels. INTERVENTION(S): Cabergoline treatment and transsphenoidal surgery. MAIN OUTCOME MEASURE(S): Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients. RESULT(S): Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas. CONCLUSION(S): This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.
OBJECTIVE: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas. DESIGN: Case report. SETTING:Outpatient practice. PATIENT(S): Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels. INTERVENTION(S): Cabergoline treatment and transsphenoidal surgery. MAIN OUTCOME MEASURE(S): Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients. RESULT(S): Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas. CONCLUSION(S): This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.
Authors: Kartik Mittal; Raj Koticha; Amit K Dey; Karan Anandpara; Rajat Agrawal; Madhva P Sarvothaman; Hemangini Thakkar Journal: Pol J Radiol Date: 2015-04-28