| Literature DB >> 16952445 |
Alessandro Bertolino1, Grazia Caforio, Vittoria Petruzzella, Valeria Latorre, Valeria Rubino, Savino Dimalta, Alessandra Torraco, Giuseppe Blasi, Roberto Quartesan, Venkata S Mattay, Joseph H Callicott, Daniel R Weinberger, Tommaso Scarabino.
Abstract
Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.Entities:
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Year: 2006 PMID： 16952445 DOI： 10.1016/j.pscychresns.2006.04.001
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222