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Literature DB >> 16952049

The insulysin (insulin degrading enzyme) enigma.

L B Hersh¹.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2006 PMID： 16952049 DOI： 10.1007/s00018-006-6238-9

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

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32 in total

1. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

Authors: Luis A Ralat; Qing Guo; Min Ren; Todd Funke; Deborah M Dickey; Lincoln R Potter; Wei-Jen Tang
Journal: J Biol Chem Date: 2010-11-22 Impact factor: 5.157

2. Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells.

Authors: Grazia R Tundo; Diego Sbardella; Sandra A De Pascali; Chiara Ciaccio; Massimo Coletta; Francesco P Fanizzi; Stefano Marini
Journal: J Biol Inorg Chem Date: 2014-12-02 Impact factor: 3.358

3. The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Authors: Diego Sbardella; Grazia R Tundo; Andrea Coletta; Julien Marcoux; Efthymia Ioanna Koufogeorgou; Chiara Ciaccio; Anna M Santoro; Danilo Milardi; Giuseppe Grasso; Paola Cozza; Marie-Pierre Bousquet-Dubouch; Stefano Marini; Massimo Coletta
Journal: Cell Mol Life Sci Date: 2018-03-28 Impact factor: 9.261

4. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

Authors: Julie Charton; Marion Gauriot; Jane Totobenazara; Nathalie Hennuyer; Julie Dumont; Damien Bosc; Xavier Marechal; Jamal Elbakali; Adrien Herledan; Xiaoan Wen; Cyril Ronco; Helene Gras-Masse; Antoine Heninot; Virginie Pottiez; Valerie Landry; Bart Staels; Wenguang G Liang; Florence Leroux; Wei-Jen Tang; Benoit Deprez; Rebecca Deprez-Poulain
Journal: Eur J Med Chem Date: 2014-12-04 Impact factor: 6.514

5. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

Authors: Enrico Malito; Luis A Ralat; Marika Manolopoulou; Julie L Tsay; Natasha L Wadlington; Wei-Jen Tang
Journal: Biochemistry Date: 2008-12-02 Impact factor: 3.162

6. Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.

Authors: Gregor Weirich; Karin Mengele; Christina Yfanti; Apostolos Gkazepis; Daniela Hellmann; Anita Welk; Cecylia Giersig; Wen-Liang Kuo; Marsha Rich Rosner; Wei-Jen Tang; Manfred Schmitt
Journal: Biol Chem Date: 2008-11 Impact factor: 3.915

The insulysin (insulin degrading enzyme) enigma.

1. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

2. Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells.

3. The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

4. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

5. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

6. Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.

7. Molecular basis for the thiol sensitivity of insulin-degrading enzyme.

8. Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid.

9. Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme.

10. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.