Literature DB >> 16951819

Molecular characterization of human Trypanosoma cruzi isolates from endemic areas in Panama.

Octavio E Sousa1, Franklyn Samudio, Corina de Juncá, José E Calzada.   

Abstract

The present work provides information on Trypanosoma cruzi genotype circulating in endemic areas of Chagas disease in Panama. A total of 26 crude stocks of T. cruzi, isolated from the blood of persons with different clinical profiles of Chagas disease were collected and crio-conserved until used. Most of the stocks had been characterized by means of isoenzyme electrophoresis on cellulose acetate membranes. The clinical profiles of infected persons included 9 (34.6%) asymptomatic and 17 acute (65.4%) including 5 (19.2%) fatal cases, 2 under 5 years old and 3 adults. A multiplex-PCR assay based on the amplification of the non-transcribed spacer of the mini-exon gene was performed. All stocks of T. cruzi included in the study were found to correspond to Tc I group. This result supports the predominance of T. cruzi-I in the transmission cycles affecting the human population in the Republic of Panama.

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Year:  2006        PMID： 16951819     DOI： 10.1590/s0074-02762006000400018

Source DB:  PubMed          Journal:  Mem Inst Oswaldo Cruz        ISSN： 0074-0276            Impact factor:   2.743


  11 in total

Review 1.  Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease.

Authors:  Louisa A Messenger; Michael A Miles; Caryn Bern
Journal:  Expert Rev Anti Infect Ther       Date:  2015-08       Impact factor: 5.091

2.  Genetic Variability and Phylogenetic Relationships within Trypanosoma cruzi I Isolated in Colombia Based on Miniexon Gene Sequences.

Authors:  Claudia Herrera; Felipe Guhl; Alejandra Falla; Anabella Fajardo; Marleny Montilla; Gustavo Adolfo Vallejo; M Dolores Bargues
Journal:  J Parasitol Res       Date:  2010-02-01

3.  Genotyping of Panamanian Trypanosoma cruzi stocks using the calmodulin 3'UTR polymorphisms.

Authors:  Adeilton Brandao; Franklyn Samudio; Octavio Fernandes; Jose E Calzada; Octavio E Sousa
Journal:  Parasitol Res       Date:  2007-12-29       Impact factor: 2.289

4.  A new endemic focus of Chagas disease in the northern region of Veraguas Province, Western Half Panama, Central America.

Authors:  Azael Saldaña; Vanessa Pineda; Inri Martinez; Giovanna Santamaria; Ana Maria Santamaria; Aracelis Miranda; Jose E Calzada
Journal:  PLoS One       Date:  2012-04-25       Impact factor: 3.240

5.  The diversity of the Chagas parasite, Trypanosoma cruzi, infecting the main Central American vector, Triatoma dimidiata, from Mexico to Colombia.

Authors:  Patricia L Dorn; Annie G McClure; Meghan D Gallaspy; Etienne Waleckx; Adrienne S Woods; Maria Carlota Monroy; Lori Stevens
Journal:  PLoS Negl Trop Dis       Date:  2017-09-28

6.  Mixed infections by different Trypanosoma cruzi discrete typing units among Chagas disease patients in an endemic community in Panama.

Authors:  Alexa Prescilla Ledezma; Roberto Blandon; Alejandro G Schijman; Alejandro Benatar; Azael Saldaña; Antonio Osuna
Journal:  PLoS One       Date:  2020-11-12       Impact factor: 3.240

7.  Surveillance and genotype characterization of zoonotic trypanosomatidae in Didelphis marsupialis in two endemic sites of rural Panama.

Authors:  Vanessa J Pineda; Kadir A González; Milixa Perea; Chystrie Rigg; José E Calzada; Luis F Chaves; Vanessa Vásquez; Franklyn Samudio; Nicole Gottdenker; Azael Saldaña
Journal:  Int J Parasitol Parasites Wildl       Date:  2021-12-06       Impact factor: 2.674

Review 8.  American trypanosomiasis, or Chagas disease, in Panama: a chronological synopsis of ecological and epidemiological research.

Authors:  Indra G Rodriguez; Jose R Loaiza
Journal:  Parasit Vectors       Date:  2017-10-10       Impact factor: 3.876

9.  Uncovering vector, parasite, blood meal and microbiome patterns from mixed-DNA specimens of the Chagas disease vector Triatoma dimidiata.

Authors:  Lucia C Orantes; Carlota Monroy; Patricia L Dorn; Lori Stevens; Donna M Rizzo; Leslie Morrissey; John P Hanley; Antonieta Guadalupe Rodas; Bethany Richards; Kimberly F Wallin; Sara Helms Cahan
Journal:  PLoS Negl Trop Dis       Date:  2018-10-18

10.  A darker chromatic variation of Rhodnius pallescens infected by specific genetic groups of Trypanosoma rangeli and Trypanosoma cruzi from Panama.

Authors:  Azael Saldaña; Ana María Santamaría; Vanessa Pineda; Vanessa Vásquez; Nicole L Gottdenker; José E Calzada
Journal:  Parasit Vectors       Date:  2018-07-16       Impact factor: 3.876
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