Literature DB >> 1695091

Interferon cures cells lytically and persistently infected with African swine fever virus in vitro.

E Paez1, F Garcia, C Gil Fernandez.   

Abstract

Human interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma) inhibit African swine fever (ASF) virus replication in Vero cells. IFN-alpha and IFN-gamma exert a synergistic inhibition. Human tumor necrosis factor (TNF) does not inhibit ASF virus replication in this cell line, but in combination with IFNs it has antiviral enhancing activity. Analysis of the mechanism of inhibition suggests that the action of these cytokines blocks a step that comes prior to DNA replication. The 2'-5' A synthetase activity is induced in Vero cells by treatment with these cytokines and is activated after ASF virus infection. More interesting is the finding that continuous treatment with IFN-alpha cures Vero cells from lytic and persistent infections with ASF virus. A potential application of IFN for the treatment of animals carrying the virus is suggested.

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Year:  1990        PMID： 1695091     DOI： 10.1007/bf01348989

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  21 in total

1.  Adenovirus infection reverses the antiviral state induced by human interferon.

Authors:  E Feduchi; L Carrasco
Journal:  FEBS Lett       Date:  1987-04-06       Impact factor: 4.124

2.  Monoclonal antibodies of African swine fever virus: antigenic differences among field virus isolates and viruses passaged in cell culture.

Authors:  B García-Barreno; A Sanz; M L Nogal; E Viñuela; L Enjuanes
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

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Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

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Authors:  E Viñuela
Journal:  Curr Top Microbiol Immunol       Date:  1985       Impact factor: 4.291

5.  Effect of interferon on Vero cells persistently infected with Sendai virus compared to Vero cells persistently infected with SSPE virus.

Authors:  M Crespi; M N Chiu; J K Struthers; B D Schoub; S F Lyons
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

Review 6.  Biochemistry of interferons and their actions.

Authors:  P Lengyel
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

7.  Adenovirus early region 1A modulation of interferon antiviral activity.

Authors:  K P Anderson; E H Fennie
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103

8.  2-5A accumulates to high levels in interferon-treated, vaccinia virus-infected cells in the absence of any inhibition of virus replication.

Authors:  A P Rice; W K Roberts; I M Kerr
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

9.  Activation of the ppp(A2'p)nA system in interferon-treated, herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase.

Authors:  P J Cayley; J A Davies; K G McCullagh; I M Kerr
Journal:  Eur J Biochem       Date:  1984-08-15

10.  Proteins specified by African swine fever virus. II. Analysis of proteins in infected cells and antigenic properties.

Authors:  E Tabarés; J Martinez; F Ruiz Gonzalvo; C Sánchez-Botija
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574
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  10 in total

1.  Changes in swine macrophage phenotype after infection with African swine fever virus: cytokine production and responsiveness to interferon-gamma and lipopolysaccharide.

Authors:  J T Whittall; R M Parkhouse
Journal:  Immunology       Date:  1997-07       Impact factor: 7.397

2.  Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.

Authors:  Vivian O'Donnell; Guillermo R Risatti; Lauren G Holinka; Peter W Krug; Jolene Carlson; Lauro Velazquez-Salinas; Paul A Azzinaro; Douglas P Gladue; Manuel V Borca
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3.  Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.

Authors:  P C Roberts; Z Lu; G F Kutish; D L Rock
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574

4.  Comprehensive Analysis of G-Quadruplexes in African Swine Fever Virus Genome Reveals Potential Antiviral Targets by G-Quadruplex Stabilizers.

Authors:  Elishiba Muturi; Fei Meng; Huan Liu; Mengwei Jiang; Hongping Wei; Hang Yang
Journal:  Front Microbiol       Date:  2021-12-16       Impact factor: 5.640

Review 5.  The Swine IFN System in Viral Infections: Major Advances and Translational Prospects.

Authors:  Elisabetta Razzuoli; Federico Armando; Livia De Paolis; Malgorzata Ciurkiewicz; Massimo Amadori
Journal:  Pathogens       Date:  2022-01-27

Review 6.  Therapeutic and Prophylactic Use of Oral, Low-Dose IFNs in Species of Veterinary Interest: Back to the Future.

Authors:  Sara Frazzini; Federica Riva; Massimo Amadori
Journal:  Vet Sci       Date:  2021-06-11

7.  Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.

Authors:  Josephine P Golding; Lynnette Goatley; Steve Goodbourn; Linda K Dixon; Geraldine Taylor; Christopher L Netherton
Journal:  Virology       Date:  2016-04-01       Impact factor: 3.616

8.  Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.

Authors:  Raquel Muñoz-Moreno; Miguel Ángel Cuesta-Geijo; Carles Martínez-Romero; Lucía Barrado-Gil; Inmaculada Galindo; Adolfo García-Sastre; Covadonga Alonso
Journal:  PLoS One       Date:  2016-04-26       Impact factor: 3.240

9.  Prediction of African Swine Fever Virus Inhibitors by Molecular Docking-Driven Machine Learning Models.

Authors:  Jiwon Choi; Jun Seop Yun; Hyeeun Song; Yong-Keol Shin; Young-Hoon Kang; Palinda Ruvan Munashingha; Jeongyeon Yoon; Nam Hee Kim; Hyun Sil Kim; Jong In Yook; Dongseob Tark; Yun-Sook Lim; Soon B Hwang
Journal:  Molecules       Date:  2021-06-11       Impact factor: 4.411

10.  Identification of African Swine Fever Virus Inhibitors through High Performance Virtual Screening Using Machine Learning.

Authors:  Jiwon Choi; Dongseob Tark; Yun-Sook Lim; Soon B Hwang
Journal:  Int J Mol Sci       Date:  2021-12-14       Impact factor: 5.923
  10 in total

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