OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obese women of reproductive age (group A: age (mean+/-SD) 35.4+/-9.2 years, Body Mass Index (BMI) 38.5+/-7 kg/m2) and 30 healthy, normal weight women (group B: age mean+/-SD 34.9+/-7.4 y., BMI 24+/-1.1 kg/m2) were included in the study. Glucose tolerance was normal in all participating women. Il-6, glutathione peroxidase and isoprostane, C-Reactive Protein (CRP), insulin, fasting plasma glucose, HOMA-IR as well as the lipid profile were evaluated. Body weight, BMI, Waist to Hip ratio (W/H) ratio, Waist Circumference (WC), %free fat mass and the %fat mass were also measured. A hypo-caloric diet was prescribed for the obese women and all participants were re-examined after six months. RESULTS: In obese women after weight loss, anthropometric obesity markers (BMI, W/H ratio), %fat, lipid profile, insulin levels and inflammation indices such as IL-6 and CRP, the oxidative stress index isoprostane, as well as glutathione peroxidase were significantly ameliorated. The levels of serum glutathione peroxidase activity were negatively correlated with IL-6 levels and were significantly increased after weight reduction. In obese women there was an association between IL-6 levels and the values of %fat, %free fat mass, insulin and HOMA-IR before and after weight loss. CONCLUSIONS: Weight loss is related to reduction of oxidative stress and inflammation; this beneficial effect could possibly be translated into reduction of cardiovascular risk in obese individuals.
OBJECTIVE: To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obesewomen and their association with markers of cardiovascular risk factors before and after weight loss. DESIGN: 36 healthy obesewomen of reproductive age (group A: age (mean+/-SD) 35.4+/-9.2 years, Body Mass Index (BMI) 38.5+/-7 kg/m2) and 30 healthy, normal weight women (group B: age mean+/-SD 34.9+/-7.4 y., BMI 24+/-1.1 kg/m2) were included in the study. Glucose tolerance was normal in all participating women. Il-6, glutathione peroxidase and isoprostane, C-Reactive Protein (CRP), insulin, fasting plasma glucose, HOMA-IR as well as the lipid profile were evaluated. Body weight, BMI, Waist to Hip ratio (W/H) ratio, Waist Circumference (WC), %free fat mass and the %fat mass were also measured. A hypo-caloric diet was prescribed for the obesewomen and all participants were re-examined after six months. RESULTS: In obesewomen after weight loss, anthropometric obesity markers (BMI, W/H ratio), %fat, lipid profile, insulin levels and inflammation indices such as IL-6 and CRP, the oxidative stress index isoprostane, as well as glutathione peroxidase were significantly ameliorated. The levels of serum glutathione peroxidase activity were negatively correlated with IL-6 levels and were significantly increased after weight reduction. In obesewomen there was an association between IL-6 levels and the values of %fat, %free fat mass, insulin and HOMA-IR before and after weight loss. CONCLUSIONS:Weight loss is related to reduction of oxidative stress and inflammation; this beneficial effect could possibly be translated into reduction of cardiovascular risk in obese individuals.
Authors: Julia Langhardt; Gesine Flehmig; Nora Klöting; Stefanie Lehmann; Thomas Ebert; Matthias Kern; Michael R Schön; Daniel Gärtner; Tobias Lohmann; Miriam Dressler; Mathias Fasshauer; Peter Kovacs; Michael Stumvoll; Arne Dietrich; Matthias Blüher Journal: Obes Facts Date: 2018-12-11 Impact factor: 3.942
Authors: Leandra Santos Baptista; Karina Ribeiro da Silva; Carolina Silva Gouveia da Pedrosa; Cesar Claudio-da-Silva; João Regis Ivar Carneiro; Marcelo Aniceto; Valéria de Mello-Coelho; Christina Maeda Takiya; Maria Isabel Doria Rossi; Radovan Borojevic Journal: Obes Surg Date: 2009-06-27 Impact factor: 4.129
Authors: Chun-Jung Huang; Matthew J McAllister; Aaron L Slusher; Heather E Webb; J Thomas Mock; Edmund O Acevedo Journal: Sports Med Open Date: 2015-09-23