| Literature DB >> 16950645 |
Carolina Jullian1, Lorena Moyano, Claudia Yañez, Claudio Olea-Azar.
Abstract
The slightly water-soluble flavonoid quercetin (QUE) and its inclusion with either beta-cyclodextrin (betaCD), hydroxypropyl-beta-cyclodextrin (HP-betaCD) or sulfobutyl ether-beta-cyclodextrin (SBE-betaCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes have been determined by phase-solubility measurements; in all cases type-A(L) diagrams have been obtained (soluble 1:1 complexes). The results showed that the inclusion ability of betaCD and its derivatives was the order: SBE-betaCD>HP-betaCD>betaCD. Kinetic studies of DPPH with QUE and CDs complexes were done. The results obtained indicated that the QUE-SBE-betaCD complex was the most reactive form. The scavenging capability of QUE and CDs complexes with DPPH and galvinoxyl was studied using ESR spectroscopy. All complexes showed a higher scavenging capability with both radicals, compare quercetin in water. Beside, these results indicated that the complexes formed maintained the quercetin antioxidant activity.Entities:
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Year: 2006 PMID： 16950645 DOI： 10.1016/j.saa.2006.07.006
Source DB: PubMed Journal: Spectrochim Acta A Mol Biomol Spectrosc ISSN： 1386-1425 Impact factor: 4.098