| Literature DB >> 16950618 |
Romen Carrillo1, Leticia G León, Tomás Martín, Víctor S Martín, José M Padrón.
Abstract
In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the alpha,beta-unsaturated ester side chain at position 2 of the THP ring.Entities:
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Year: 2006 PMID： 16950618 DOI： 10.1016/j.bmcl.2006.08.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823