BACKGROUND: This study identified predictors of patients for whom carotid artery intima-media thickness (CIMT) measurement and determination of vascular age could change cardiovascular disease (CVD) risk assessment. METHODS: We studied consecutive patients who were asymptomatic and nondiabetic, referred for ultrasound measurement of CIMT. Individuals with CIMT 75th percentile or greater for age, sex, and race were defined as having advanced subclinical atherosclerosis. CIMT values were converted to vascular age estimates and were used to modify Framingham 10-year CVD risk estimates. RESULTS: Of 506 patients, 261 (51.6%) were not taking lipid-lowering therapy. Advanced subclinical atherosclerosis was present in 77 (30%). There were 62 patients (23.8%) with a change in CVD risk of 5% or more. Predictors of 5% or more change in CVD risk were systolic blood pressure (P < .001), total/high-density lipoprotein cholesterol ratio (P < .001), and male sex (P < .001). Of the 97 patients at moderate or moderately high risk, 56.7% changed risk classification. CONCLUSIONS: Measurement of CIMT and determination of vascular age can identify individuals with advanced subclinical atherosclerosis, resulting in clinically meaningful alterations in CVD risk estimates.
BACKGROUND: This study identified predictors of patients for whom carotid artery intima-media thickness (CIMT) measurement and determination of vascular age could change cardiovascular disease (CVD) risk assessment. METHODS: We studied consecutive patients who were asymptomatic and nondiabetic, referred for ultrasound measurement of CIMT. Individuals with CIMT 75th percentile or greater for age, sex, and race were defined as having advanced subclinical atherosclerosis. CIMT values were converted to vascular age estimates and were used to modify Framingham 10-year CVD risk estimates. RESULTS: Of 506 patients, 261 (51.6%) were not taking lipid-lowering therapy. Advanced subclinical atherosclerosis was present in 77 (30%). There were 62 patients (23.8%) with a change in CVD risk of 5% or more. Predictors of 5% or more change in CVD risk were systolic blood pressure (P < .001), total/high-density lipoprotein cholesterol ratio (P < .001), and male sex (P < .001). Of the 97 patients at moderate or moderately high risk, 56.7% changed risk classification. CONCLUSIONS: Measurement of CIMT and determination of vascular age can identify individuals with advanced subclinical atherosclerosis, resulting in clinically meaningful alterations in CVD risk estimates.
Authors: Ankush Jamthikar; Deep Gupta; Elisa Cuadrado-Godia; Anudeep Puvvula; Narendra N Khanna; Luca Saba; Klaudija Viskovic; Sophie Mavrogeni; Monika Turk; John R Laird; Gyan Pareek; Martin Miner; Petros P Sfikakis; Athanasios Protogerou; George D Kitas; Chithra Shankar; Andrew Nicolaides; Vijay Viswanathan; Aditya Sharma; Jasjit S Suri Journal: Cardiovasc Diagn Ther Date: 2020-08
Authors: Young Jin Youn; Nam Seok Lee; Jang-Young Kim; Jun-Won Lee; Joong-Kyung Sung; Sung-Gyun Ahn; Byung-Su You; Seung-Hwan Lee; Junghan Yoon; Kyung-Hoon Choe; Sang Baek Koh; Jong Ku Park Journal: J Korean Med Sci Date: 2011-02-25 Impact factor: 2.153
Authors: Michael C Langham; Erin K Englund; Emile R Mohler; Cheng Li; Zachary B Rodgers; Thomas F Floyd; Felix W Wehrli Journal: J Cardiovasc Magn Reson Date: 2013-02-13 Impact factor: 5.364