BACKGROUND: Although abnormalities in reward processing have been proposed to underlie attention-deficit/hyperactivity disorder (ADHD), this link has not been tested explicitly with neural probes. METHODS: This hypothesis was tested by using fMRI to compare neural activity within the striatum in individuals with ADHD and healthy controls during a reward-anticipation task that has been shown previously to produce reliable increases in ventral striatum activity in healthy adults and healthy adolescents. Eleven adolescents with ADHD (5 off medication and 6 medication-naïve) and 11 healthy controls (ages 12-17 y) were included. Groups were matched for age, gender, and intelligence quotient. RESULTS: We found reduced ventral striatal activation in adolescents with ADHD during reward anticipation, relative to healthy controls. Moreover, ventral striatal activation was negatively correlated with parent-rated hyperactive/impulsive symptoms across the entire sample. CONCLUSIONS: These findings provide neural evidence that symptoms of ADHD, and impulsivity or hyperactivity in particular, may involve diminished reward anticipation, in addition to commonly observed executive dysfunction.
BACKGROUND: Although abnormalities in reward processing have been proposed to underlie attention-deficit/hyperactivity disorder (ADHD), this link has not been tested explicitly with neural probes. METHODS: This hypothesis was tested by using fMRI to compare neural activity within the striatum in individuals with ADHD and healthy controls during a reward-anticipation task that has been shown previously to produce reliable increases in ventral striatum activity in healthy adults and healthy adolescents. Eleven adolescents with ADHD (5 off medication and 6 medication-naïve) and 11 healthy controls (ages 12-17 y) were included. Groups were matched for age, gender, and intelligence quotient. RESULTS: We found reduced ventral striatal activation in adolescents with ADHD during reward anticipation, relative to healthy controls. Moreover, ventral striatal activation was negatively correlated with parent-rated hyperactive/impulsive symptoms across the entire sample. CONCLUSIONS: These findings provide neural evidence that symptoms of ADHD, and impulsivity or hyperactivity in particular, may involve diminished reward anticipation, in addition to commonly observed executive dysfunction.
Authors: Melissa M Andrews; Shashwath A Meda; Andre D Thomas; Marc N Potenza; John H Krystal; Patrick Worhunsky; Michael C Stevens; Stephanie O'Malley; Gregory A Book; Brady Reynolds; Godfrey D Pearlson Journal: Biol Psychiatry Date: 2010-12-03 Impact factor: 13.382
Authors: Yannis Paloyelis; Mitul A Mehta; Stephen V Faraone; Philip Asherson; Jonna Kuntsi Journal: J Am Acad Child Adolesc Psychiatry Date: 2012-06-05 Impact factor: 8.829
Authors: Genna Bebko; Michele A Bertocci; Jay C Fournier; Amanda K Hinze; Lisa Bonar; Jorge R C Almeida; Susan B Perlman; Amelia Versace; Claudiu Schirda; Michael Travis; Mary Kay Gill; Christine Demeter; Vaibhav A Diwadkar; Gary Ciuffetelli; Eric Rodriguez; Thomas Olino; Erika Forbes; Jeffrey L Sunshine; Scott K Holland; Robert A Kowatch; Boris Birmaher; David Axelson; Sarah M Horwitz; L Eugene Arnold; Mary A Fristad; Eric A Youngstrom; Robert L Findling; Mary L Phillips Journal: JAMA Psychiatry Date: 2014-01 Impact factor: 21.596