Literature DB >> 16949281

Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.

Nicholas J Lawrence1, Richard P Patterson, Li-Ling Ooi, Darren Cook, Sylvie Ducki.   

Abstract

Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones.

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Year:  2006        PMID： 16949281     DOI： 10.1016/j.bmcl.2006.08.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

Authors:  Casey J Maguire; Graham J Carlson; Jacob W Ford; Tracy E Strecker; Ernest Hamel; Mary Lynn Trawick; Kevin G Pinney
Journal:  Medchemcomm       Date:  2019-06-04       Impact factor: 3.597

2.  Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.

Authors:  Lívia B Salum; Wanessa F Altei; Louise D Chiaradia; Marlon N S Cordeiro; Rafael R Canevarolo; Carolina P S Melo; Evelyn Winter; Bruno Mattei; Hikmat N Daghestani; Maria Cláudia Santos-Silva; Tânia B Creczynski-Pasa; Rosendo A Yunes; José A Yunes; Adriano D Andricopulo; Billy W Day; Ricardo J Nunes; Andreas Vogt
Journal:  Eur J Med Chem       Date:  2013-03-06       Impact factor: 6.514

3.  (E)-3-(6-Nitro-benzo[d][1,3]dioxol-5-yl)-1-(2,4,6-trimethoxy-phen-yl)prop-2-en-1-one.

Authors:  Hossein Loghmani-Khouzani; Noorsaadah Abdul Rahman; Ward T Robinson; Marzieh Yaeghoobi; Reza Kia
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-09-26

4.  Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Po-Kai Huang; Hsu-Chin Chan; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Bioorg Med Chem       Date:  2013-06-26       Impact factor: 3.641

5.  Triphenyl(3,4,5-trimethoxy-benzyl)-phospho-nium chloride monohydrate.

Authors:  Alice M Barkell; Jonathan Sharp; Stephen J Simpson
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-06

6.  A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.

Authors:  Ayad A Al-Hamashi; Radhika Koranne; Samkeliso Dlamini; Abdulateef Alqahtani; Endri Karaj; Maisha S Rashid; Joseph R Knoff; Matthew Dunworth; Mary Kay H Pflum; Robert A Casero; Lalith Perera; William R Taylor; L M Viranga Tillekeratne
Journal:  Bioorg Chem       Date:  2021-08-30       Impact factor: 5.275

Review 7.  A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors.

Authors:  Wenjing Liu; Min He; Yongjun Li; Zhiyun Peng; Guangcheng Wang
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

8.  Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.

Authors:  Vasilis Androutsopoulos; Randolph R J Arroo; John F Hall; Somchaiya Surichan; Gerry A Potter
Journal:  Breast Cancer Res       Date:  2008-05-02       Impact factor: 6.466

9.  4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

Authors:  Qi Qu; Bingguang Dai; Bo Yang; Xuelian Li; Yimin Liu; Fuling Zhang
Journal:  Biomed Res Int       Date:  2014-06-09       Impact factor: 3.411

10.  Insights on a new sulfonamide chalcone with potential antineoplastic application.

Authors:  Patricia R S Wenceslau; Renata L G de Paula; Vitor S Duarte; Giulio D C D'Oliveira; Laura M M Guimarães; Caridad N Pérez; Leonardo L Borges; José L R Martins; James O Fajemiroye; Chris H J Franco; Pal Perjesi; Hamilton B Napolitano
Journal:  J Mol Model       Date:  2021-06-26       Impact factor: 1.810
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