Literature DB >> 1694860

Fatty acid chain is a critical epitope for antiphospholipid antibody.

R A Levy1, A E Gharavi, L R Sammaritano, L Habina, M D Lockshin.   

Abstract

To explore the role of phospholipid fatty acids in binding of antiphospholipid antibody (aPL) in ELISA, we tested aPL binding to phospholipids containing fatty acids of varying chain length and degree of saturation using direct ELISA and inhibition methods. Polyclonal IgG and IgM human aPL's bind to C18:1 phosphatidylglycerol (PG) better than to C18:0 PG or C18:2 PG. Binding is greater to C18 than to C14:0 or C16:0 PGs; aPL's do not bind to C12:0 PG. aPL binding is not inhibited by C18:1 diacylglycerol, glycerol-3-phosphate, myoinositol, or myoinositol phosphate. The fatty acid chains are critical determinants for antigen recognition and, by projection, biological activity of aPL.

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Year:  1990        PMID： 1694860     DOI： 10.1007/bf00917913

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  17 in total

1.  Anticardiolipin antibody.

Authors:  M D Lockshin
Journal:  Arthritis Rheum       Date:  1987-04

2.  Antibodies to phospholipids and liposomes: binding of antibodies to cells.

Authors:  W E Fogler; G M Swartz; C R Alving
Journal:  Biochim Biophys Acta       Date:  1987-10-02

3.  Reaction patterns of monoclonal antibodies to DNA.

Authors:  R J Smeenk; K Brinkman; H G van den Brink; A A Westgeest
Journal:  J Immunol       Date:  1988-06-01       Impact factor: 5.422

4.  Enhancement of anti-phospholipid antibody activity by Tween 20.

Authors:  A E Gharavi; M D Lockshin
Journal:  J Immunol Methods       Date:  1988-11-10       Impact factor: 2.303

5.  Immune mediated mechanism for thrombosis: antiphospholipid antibody binding to platelet membranes.

Authors:  M A Khamashta; E N Harris; A E Gharavi; G Derue; A Gil; J J Vázquez; G R Hughes
Journal:  Ann Rheum Dis       Date:  1988-10       Impact factor: 19.103

6.  Cross-reactions of nucleic acids with monoclonal antibodies to phosphatidylinositol phosphate and cholesterol.

Authors:  B D Stollar; T McInerney; T Gavron; N M Wassef; G M Swartz; C R Alving
Journal:  Mol Immunol       Date:  1989-01       Impact factor: 4.407

7.  Antibodies to liposomes, phospholipids and phosphate esters.

Authors:  C R Alving
Journal:  Chem Phys Lipids       Date:  1986 Jun-Jul       Impact factor: 3.329

8.  Phase transition characteristics of diphosphatidyl-glycerol (cardiolipin) and stereoisomeric phosphatidyldiacylglycerol bilayers. Mono- and divalent metal ion effects.

Authors:  S Rainier; M K Jain; F Ramirez; P V Ioannou; J F Marecek; R Wagner
Journal:  Biochim Biophys Acta       Date:  1979-12-04

9.  Polylysine induces pH-dependent fusion of acidic phospholipid vesicles: a model for polycation-induced fusion.

Authors:  A Walter; C J Steer; R Blumenthal
Journal:  Biochim Biophys Acta       Date:  1986-10-09

10.  IgG but not IgM anti-phospholipid antibody binding is temperature dependent.

Authors:  M D Lockshin; T Qamar; R A Levy; M P Best
Journal:  J Clin Immunol       Date:  1988-05       Impact factor: 8.317
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  8 in total

1.  Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein.

Authors:  S Hörkkö; E Miller; E Dudl; P Reaven; L K Curtiss; N J Zvaifler; R Terkeltaub; S S Pierangeli; D W Branch; W Palinski; J L Witztum
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

Review 2.  Antiphospholipid antibodies and the antiphospholipid syndrome.

Authors:  E N Harris; S S Pierangeli
Journal:  Springer Semin Immunopathol       Date:  1994

3.  Lysophosphatidylethanolamine is the antigen to which apparent antibody to phosphatidylethanolamine binds.

Authors:  T Qamar; A E Gharavi; R A Levy; M D Lockshin
Journal:  J Clin Immunol       Date:  1990-07       Impact factor: 8.317

4.  Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice.

Authors:  A Berger; M E Gershwin; J B German
Journal:  Lipids       Date:  1992-08       Impact factor: 1.880

5.  Human autoantibodies to diacyl-phosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains.

Authors:  C C F C Laurino; M J Fritzler; R A Mortara; N P Silva; I C Almeida; L E C Andrade
Journal:  Clin Exp Immunol       Date:  2006-03       Impact factor: 4.330

6.  Coincidence of familial platelet glycoprotein Ib/IX deficiency (Bernard-Soulier syndrome), idiopathic autoantibody against platelet glycoprotein Ib/IX, familial appearance of antiphospholipid antibodies, and familial factor XII deficiency.

Authors:  W Korte; C Baumgartner; A Feldges; C Knöpfl; S Lutz; A Lenz; W Riesen; L Schmid
Journal:  Ann Hematol       Date:  1994-02       Impact factor: 3.673

7.  Antiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis.

Authors:  Cristiano Alessandri; Maurizio Sorice; Michele Bombardieri; Paola Conigliaro; Agostina Longo; Tina Garofalo; Valeria Manganelli; Fabrizio Conti; Mauro Degli Esposti; Guido Valesini
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156

8.  Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis.

Authors:  Roy A Garvin
Journal:  J Lipids       Date:  2015-08-12
  8 in total

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