Literature DB >> 1694764

Structure of human myeloma IgG3 Kuc.

S Ryazantsev1, V Tishchenko, V Vasiliev, V Zav'yalov, V Abramov.   

Abstract

An electron microscopy study of human myeloma IgG3 Kuc has shown that the hinge region in an intact molecule is in a compact state. The subunits are not fixed rigidly and are very mobile. These data are supported by results of ultracentrifugation and microcalorimetry. Non-extremal denaturating effects (pH 4.0, 20 degrees C or pH 7.8, 65 degrees C) lead to 'unfolding' of the hinge region which has a rod-like shape in electron micrographs.

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Year:  1990        PMID： 1694764     DOI： 10.1111/j.1432-1033.1990.tb15588.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  4 in total

1.  Small-angle neutron scattering characterization of monoclonal antibody conformations and interactions at high concentrations.

Authors:  Eric J Yearley; Isidro E Zarraga; Steven J Shire; Thomas M Scherer; Yatin Gokarn; Norman J Wagner; Yun Liu
Journal:  Biophys J       Date:  2013-08-06       Impact factor: 4.033

2.  Coming together at the hinges: Therapeutic prospects of IgG3.

Authors:  Thach H Chu; Edward F Patz; Margaret E Ackerman
Journal:  MAbs       Date:  2021 Jan-Dec       Impact factor: 5.857

3.  Three-dimensional structure of the human myeloma IgG2.

Authors:  Sergey Ryazantsev; Vladimir Tischenko; Christopher Nguyen; Vyacheslav Abramov; Vladimir Zav'yalov
Journal:  PLoS One       Date:  2013-06-07       Impact factor: 3.240

4.  Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies.

Authors:  Thach H Chu; Andrew R Crowley; Iara Backes; Cheryl Chang; Matthew Tay; Thomas Broge; Marina Tuyishime; Guido Ferrari; Michael S Seaman; Simone I Richardson; Georgia D Tomaras; Galit Alter; David Leib; Margaret E Ackerman
Journal:  PLoS Pathog       Date:  2020-02-24       Impact factor: 6.823
  4 in total

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