| Literature DB >> 169471 |
Abstract
The presence of "high-affinity-saturable" binding sites for thyroid hormones of similar characteristics not only in isolated nuclei but in all the major extranuclear cellular components, as well as the failure of cytosol to promote nuclear binding, invalidates the analogy with steroid hormone receptors and necessitates a more critical assessment of the physiological relevance of current approaches to binding of thyroid hormone in vitro nuclear preparations.Mesh：
Substances：
Year: 1975 PMID： 169471 DOI： 10.1038/257018a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962