Literature DB >> 16946745

Scleral penetration force requirements for commonly used intravitreal needles.

J S Pulido1, M E Zobitz, K-N An.   

Abstract

INTRODUCTION: Repeated intraocular injections have become routine practice. It is important to determine how to make them as painless as possible. We wished to examine the force required to penetrate the sclera with different gauge needles.
METHODS: Recently enucleated eyes had 4 mm scleral punch biopsies performed. The scleral disks were mounted on a fixed load cell and either a new needle or a needle that had previously penetrated a rubber vial was attached to a linear stage and the maximum penetration force measured.
RESULTS: The 27-gauge needles required almost twice as much force to penetrate the sclera than either the 30- or the 31-gauge. In addition, the 30- and 31-gauge appeared to require similar force. In all cases, following vial perforation, there was an increase in the amount of force required to penetrate the sclera. The amount of force was variable. DISCUSSION: Smaller gauge needles require less force to penetrate the sclera and needles that have been used to penetrate rubber vials require more force.

Mesh:

Year:  2006        PMID: 16946745     DOI: 10.1038/sj.eye.6702577

Source DB:  PubMed          Journal:  Eye (Lond)        ISSN: 0950-222X            Impact factor:   3.775


  9 in total

1.  Indentation and needle insertion properties of the human eye.

Authors:  A Matthews; C Hutnik; K Hill; T Newson; T Chan; G Campbell
Journal:  Eye (Lond)       Date:  2014-05-09       Impact factor: 3.775

2.  Novel Needle for Intravitreal Drug Delivery: Comparative Study of Needle Tip Aspirates, Injection Stream and Penetration Forces.

Authors:  Lyubomyr M Lytvynchuk; Goran Petrovski; Adien Dam; Joep Hiemstra; Tobias Wimmer; Iryna Savytska; Susanne Binder; Knut Stieger
Journal:  Clin Ophthalmol       Date:  2021-02-19

3.  Assessment of patient pain experience during intravitreal 27-gauge bevacizumab and 30-gauge ranibizumab injection.

Authors:  Mete Güler; Burak Bilgin; Musa Çapkın; Ali Şimşek; Şemsettin Bilak
Journal:  Korean J Ophthalmol       Date:  2015-05-20

4.  Intravitreal Injections of Bevacizumab: The Impact of Needle Size in Intraocular Pressure and Pain.

Authors:  Mónica Loureiro; Rita Matos; Paula Sepulveda; Dália Meira
Journal:  J Curr Glaucoma Pract       Date:  2017-08-05

5.  Comparative cyto-histological study of needle tip aspirates and entry sites after intravitreal injection using different needle types.

Authors:  Lyubomyr Lytvynchuk; Andrij Sergienko; Iryna Savytska; Réka Albert; Carl Glittenberg; Susanne Binder; Goran Petrovski
Journal:  PLoS One       Date:  2017-07-10       Impact factor: 3.240

6.  Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery.

Authors:  Raghu Raj Singh Thakur; Ismaiel A Tekko; Farhan Al-Shammari; Ahlam A Ali; Helen McCarthy; Ryan F Donnelly
Journal:  Drug Deliv Transl Res       Date:  2016-12       Impact factor: 4.617

7.  Subjective and objective measures of the patient experience before, during, and after intravitreal anti-vascular endothelial growth factor injections.

Authors:  Suresh Mekala; Pankaja Dhoble; C R Vishwaraj; Ashish M Khodifad; Olivia M Hess; G S Lavanya
Journal:  Indian J Ophthalmol       Date:  2021-04       Impact factor: 1.848

8.  Real-time measurement of intraocular pressure variation during automatic intravitreal injections: An ex-vivo experimental study using porcine eyes.

Authors:  Ikjong Park; Han Sang Park; Hong Kyun Kim; Wan Kyun Chung; Keehoon Kim
Journal:  PLoS One       Date:  2021-08-26       Impact factor: 3.240

9.  Survey of intravitreal injection techniques among retina specialists in Israel.

Authors:  Ori Segal; Yael Segal-Trivitz; Arie Y Nemet; Noa Geffen; Ronit Nesher; Michael Mimouni
Journal:  Clin Ophthalmol       Date:  2016-06-14
  9 in total

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