| Literature DB >> 16945543 |
Elisa S C Pôças1, Daniele V S Lopes, Alcides J M da Silva, Paulo H C Pimenta, Fernanda B Leitão, Chaquip D Netto, Camilla D Buarque, Flávia V Brito, Paulo R R Costa, François Noël.
Abstract
Coumestans 2a-i, bearing different patterns of substitution in A- and D-rings, were synthesized and evaluated as inhibitors of kidney Na+, K+ -ATPase and ligands for the central benzodiazepine (BZP) receptor. The presence of a hydroxyl group in position 2 favours the effect on Na+, K+ -ATPase but decreases the affinity for the BZP receptor, allowing the design of more selective molecules than the natural wedelolactone. On the other hand, the presence of a catechol in ring D is important for the effect on both molecular targets.Entities:
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Year: 2006 PMID： 16945543 DOI： 10.1016/j.bmc.2006.07.053
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641