| Literature DB >> 16945526 |
Paul R O Whittamore1, Matthew S Addie, Stuart N L Bennett, Alan M Birch, Michael Butters, Linda Godfrey, Peter W Kenny, Andrew D Morley, Paul M Murray, Nikos G Oikonomakos, Ludovic R Otterbein, Andrew D Pannifer, Jeremy S Parker, Kristy Readman, Pawel S Siedlecki, Paul Schofield, Andy Stocker, Melvyn J Taylor, Linda A Townsend, David P Whalley, Jennifer Whitehouse.
Abstract
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.Entities:
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Year: 2006 PMID： 16945526 DOI： 10.1016/j.bmcl.2006.08.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823