| Literature DB >> 16945414 |
Jana Rulcová1, Václava Zmeková, Zuzana Zemanová, Hana Klamová, Jana Moravcová.
Abstract
We compared the effect of control genes (CG): total Abelson (total-ABL), beta-2-microglobulin (B2M) and beta-glucuronidase (GUS), recommended in the Europe Against Cancer (EAC) program, on real-time BCR-ABL monitoring in patients with chronic myeloid leukemia (CML). We focused on the stability of CG expressions during therapy and the effect of the CGs on BCR-ABL ability to characterize the disease status and disease prognosis, issues that have not been addressed yet. The results showed B2M as a very convenient CG for BCR-ABL monitoring. On the contrary, the widely used total-ABL was not confirmed as appropriate for normalization of gene expression in CML.Entities:
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Year: 2006 PMID: 16945414 DOI: 10.1016/j.leukres.2006.07.021
Source DB: PubMed Journal: Leuk Res ISSN: 0145-2126 Impact factor: 3.156