Literature DB >> 16944992

The colorectal carcinoma prognosis factors. Significance of diagnosis delay.

E Gómez-Domínguez1, M Trapero-Marugán, A J del Pozo, J Cantero, J P Gisbert, J Maté.   

Abstract

INTRODUCTION: detection of early-stage colorectal carcinoma (CRC)--( Dukes A or B)--provides better survival rates in these patients. Thus, the effectiveness of screening programs in asymptomatic patients or of early diagnosis in symptomatic individuals has been postulated. The aim of this study was to establish whether a delay in diagnosis or other factors are related to CRC stage. PATIENTS AND METHODS: a retrospective study was performed on 96 patients with CRC. Age at diagnosis, gender distribution, intestinal disorders, diagnosis delay, primary sign and -regarding CRC- localization, stage (Dukes) and grade of differentiation (well differentiated; non-well differentiated; poorly differentiated) were recorded.
RESULTS: diagnosis delay was 185 +/- 190 days. Patients delay in obtaining a diagnosis was 119 +/- 158 days. In 40% of patients CRC was diagnosed at an early stage (Dukes A or B), and in 13% CRC was poorly differentiated. The only factor with an independent effect on Dukes stage was tumor differentiation (p: 0.0012). Distal location was associated with less advanced tumors without statistical significance (p: 0.156).
CONCLUSION: based on the presented data, a greater effort regarding screening programs for healthy people seems warranted, as improved survival has been demonstrated when diagnosis delay is reduced, particularly in patients with the highest mean delay.

Entities:  

Mesh:

Year:  2006        PMID: 16944992     DOI: 10.4321/s1130-01082006000500002

Source DB:  PubMed          Journal:  Rev Esp Enferm Dig        ISSN: 1130-0108            Impact factor:   2.086


  6 in total

1.  Why so late?!--delay in treatment of colorectal cancer is socially determined.

Authors:  Mike Ralf Langenbach; Stefan Sauerland; Karl-Wilhelm Kröbel; Hubert Zirngibl
Journal:  Langenbecks Arch Surg       Date:  2010-06-27       Impact factor: 3.445

2.  Postreferral colonoscopy delays in diagnosis of colorectal cancer: a mixed-methods analysis.

Authors:  Hardeep Singh; Rashid Khan; Traber Davis Giardina; Lindsey Wilson Paul; Kuang Daci; Milena Gould; Hashem El-Serag
Journal:  Qual Manag Health Care       Date:  2012 Oct-Dec       Impact factor: 0.926

3.  Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies.

Authors:  Sandra F Martins; Rui M Reis; Antonio Mesquita Rodrigues; Fátima Baltazar; Adhemar Longatto Filho
Journal:  World J Clin Oncol       Date:  2011-06-10

4.  The Novel Target of Colorectal Carcinoma: TRIM44 Regulates Cell Migration and Invasion via Activation of CXCR4/NF-κB Signaling.

Authors:  Tianlei Kou; Deqian Sha; Fei Wang; Tao He; Xuan He
Journal:  Cell Biochem Biophys       Date:  2020-11-05       Impact factor: 2.194

5.  Missed opportunities to initiate endoscopic evaluation for colorectal cancer diagnosis.

Authors:  Hardeep Singh; Kuang Daci; Laura A Petersen; Clyde Collins; Nancy J Petersen; Anila Shethia; Hashem B El-Serag
Journal:  Am J Gastroenterol       Date:  2009-06-23       Impact factor: 10.864

6.  Effect of diagnostic delay on survival in patients with colorectal cancer: a retrospective cohort study.

Authors:  Salvador Pita-Fernández; Luis González-Sáez; Beatriz López-Calviño; Teresa Seoane-Pillado; Elena Rodríguez-Camacho; Alejandro Pazos-Sierra; Paloma González-Santamaría; Sonia Pértega-Díaz
Journal:  BMC Cancer       Date:  2016-08-22       Impact factor: 4.430

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.