Literature DB >> 16943651

Clinical trials in pediatric traumatic brain injury: unique challenges and potential responses.

JoAnne E Natale1, Jill G Joseph, Robert K Pretzlaff, Tomas J Silber, Anne-Marie Guerguerian.   

Abstract

In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society. Copyright (c) 2006 S. Karger AG, Basel.

Entities:  

Mesh：

Year:  2006        PMID： 16943651     DOI： 10.1159/000094154

Source DB:  PubMed          Journal:  Dev Neurosci        ISSN： 0378-5866            Impact factor:   2.984


  8 in total

1.  Therapeutic hypothermia after pediatric cardiac arrest trials: the vanguard phase experience and implications for other trials.

Authors:  Victoria L Pemberton; Brittan Browning; Angie Webster; J Michael Dean; Frank W Moler
Journal:  Pediatr Crit Care Med       Date:  2013-01       Impact factor: 3.624

2.  Factors affecting consent in pediatric critical care research.

Authors:  Kusum Menon; Roxanne E Ward; Isabelle Gaboury; Margot Thomas; Ari Joffe; Karen Burns; Deborah Cook
Journal:  Intensive Care Med       Date:  2011-11-26       Impact factor: 17.440

3.  Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research.

Authors:  Andrew I R Maas; David K Menon; Hester F Lingsma; Jose A Pineda; M Elizabeth Sandel; Geoffrey T Manley
Journal:  J Neurotrauma       Date:  2011-08-29       Impact factor: 5.269

4.  Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain.

Authors:  Bridgette D Semple; Alpa Trivedi; Kayleen Gimlin; Linda J Noble-Haeusslein
Journal:  Neurobiol Dis       Date:  2014-12-09       Impact factor: 5.996

Review 5.  Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury.

Authors:  Courtney L Robertson; Susanna Scafidi; Mary C McKenna; Gary Fiskum
Journal:  Exp Neurol       Date:  2009-05-07       Impact factor: 5.330

Review 6.  Multimodality neuromonitoring in severe pediatric traumatic brain injury.

Authors:  Adam M H Young; Mathew R Guilfoyle; Joseph Donnelly; Peter Smielewski; Shruti Agarwal; Marek Czosnyka; Peter J Hutchinson
Journal:  Pediatr Res       Date:  2017-12-20       Impact factor: 3.756

7.  Informed consent in paediatric critical care research--a South African perspective.

Authors:  Brenda M Morrow; Andrew C Argent; Sharon Kling
Journal:  BMC Med Ethics       Date:  2015-09-09       Impact factor: 2.652

8.  U.S. Trends of ED Visits for Pediatric Traumatic Brain Injuries: Implications for Clinical Trials.

Authors:  Cheng Chen; Junxin Shi; Rachel M Stanley; Eric A Sribnick; Jonathan I Groner; Henry Xiang
Journal:  Int J Environ Res Public Health       Date:  2017-04-13       Impact factor: 3.390
  8 in total

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