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Literature DB >> 16943623

The alpha-aminoadipate pathway for lysine biosynthesis in fungi.

Hengyu Xu¹, Babak Andi, Jinghua Qian, Ann H West, Paul F Cook.

Abstract

This review provides a description of the biochemistry and enzymology of the alpha-aminoadipate pathway for lysine biosynthesis in fungi. The alpha-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.

Entities: Chemical

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Year: 2006 PMID： 16943623 DOI： 10.1385/CBB:46:1:43

Source DB: PubMed Journal: Cell Biochem Biophys ISSN： 1085-9195 Impact factor: 2.194

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Cited

53 in total

1. Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase.

Authors: Stacie L Bulfer; Thomas J McQuade; Martha J Larsen; Raymond C Trievel
Journal: Anal Biochem Date: 2010-11-10 Impact factor: 3.365

2. Homocitrate synthase expression and lysine content in fruiting body of different developmental stages in Flammulina velutipes.

Authors: Fang Liu; Wei Wang; Bing-Zhi Chen; Bao-Gui Xie
Journal: Curr Microbiol Date: 2015-02-28 Impact factor: 2.188

3. A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.

Authors: Hengyu Xu; Susan S Alguindigue; Ann H West; Paul F Cook
Journal: Biochemistry Date: 2007-01-23 Impact factor: 3.162

4. The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.

Authors: Eunsoo Do; Minji Park; Guanggan Hu; Mélissa Caza; James W Kronstad; Won Hee Jung
Journal: Biochem Biophys Res Commun Date: 2016-06-25 Impact factor: 3.575

10. 13C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucose.

Authors: Paula Jouhten; Esa Pitkänen; Tiina Pakula; Markku Saloheimo; Merja Penttilä; Hannu Maaheimo
Journal: BMC Syst Biol Date: 2009-10-29

The alpha-aminoadipate pathway for lysine biosynthesis in fungi.

1. Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase.

2. Homocitrate synthase expression and lysine content in fruiting body of different developmental stages in Flammulina velutipes.

3. A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.

4. The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.

5. Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction.

Review 6. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.

Review 7. New insights into the metabolism of aspartate-family amino acids in plant seeds.

8. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.

9. Structural basis for L-lysine feedback inhibition of homocitrate synthase.

10. 13C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucose.