Literature DB >> 16943583

The dual effect of isoproterenol on insulin release is suppressed in pancreatic islets from hypothalamic obese rats.

Anderson Carlos Marçal1, Sabrina Grassiolli, Diego Neves da Rocha, Marcelo Aguilar Puzzi, Clarice Gravena, Dionízia Xavier Scomparin, Paulo Cezar de Freitas Mathias.   

Abstract

Hyperinsulinemia in obesity has been attributed to insulin oversecretion by pancreatic beta-cells. Beta-cells are equipped with cholinergic and adrenergic receptors; whereas overall acetylcholine action is to potentiate, catecholamines' effect is to inhibit glucose-induced insulin release (GIIR) via alpha2-adrenoceptor. However, it has been shown that beta-adrenergic agonists potentiate glucose response. GIIR was studied in pancreatic islets from hyperinsulinemic adult obese rats, obtained by L-glutamate monosodium (MSG) neonatal treatment. Islets from MSG-rats were more glucose responsive than control ones. Isoproterenol, a beta-adrenergic agonist, inhibited the GIIR in islets from MSG-obese rats. Results indicate that MSG treatment causes alteration on function of beta-cell adrenoceptors.

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Year:  2006        PMID： 16943583     DOI： 10.1385/endo:29:3:445

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  52 in total

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Journal:  Circ Res       Date:  1999 Jan 8-22       Impact factor: 17.367
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  5 in total

1.  Pancreatic islets from hypothalamic obese rats maintain K+ATP channel-dependent but not -independent pathways on glucose-induced insulin release process.

Authors:  Sabrina Grassiolli; Maria Lúcia Bonfleur; Dionizia Xavier Scomparin; Paulo Cezar de Freitas Mathias
Journal:  Endocrine       Date:  2006-10       Impact factor: 3.633

2.  Fat storage is partially dependent on vagal activity and insulin secretion of hypothalamic obese rat.

Authors:  Sandra Lucinei Balbo; Sabrina Grassiolli; Rosane Aparecida Ribeiro; Maria Lúcia Bonfleur; Clarice Gravena; Marcia do Nascimento Brito; Ana Eliza Andreazzi; Paulo Cezar de Freitas Mathias; Rosana Torrezan
Journal:  Endocrine       Date:  2007-04       Impact factor: 3.633

3.  Cross-fostering reduces obesity induced by early exposure to monosodium glutamate in male rats.

Authors:  Rosiane Aparecida Miranda; Claudinéia Conationi da Silva Franco; Júlio Cezar de Oliveira; Luiz Felipe Barella; Laize Peron Tófolo; Tatiane Aparecida Ribeiro; Audrei Pavanello; Ellen Paula Santos da Conceição; Rosana Torrezan; James Armitage; Patrícia Cristina Lisboa; Egberto Gaspar de Moura; Paulo Cezar de Freitas Mathias; Elaine Vieira
Journal:  Endocrine       Date:  2016-04-26       Impact factor: 3.633

4.  Impaired sympathoadrenal axis function contributes to enhanced insulin secretion in prediabetic obese rats.

Authors:  Ana Eliza Andreazzi; Sabrina Grassiolli; Paula Beatriz Marangon; Adriana Gallego Martins; Júlio Cézar de Oliveira; Rosana Torrezan; Clarice Gravena; Raúl Marcel González Garcia; Paulo Cezar de Freitas Mathias
Journal:  Exp Diabetes Res       Date:  2011-08-16

5.  Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets.

Authors:  Silvano Piovan; Audrei Pavanello; Giuliana Maria Ledesma Peixoto; Camila Cristina Ianoni Matiusso; Ana Maria Praxedes de Moraes; Isabela Peixoto Martins; Ananda Malta; Kesia Palma-Rigo; Claudinéia Conationi da Silva Franco; Paula Gimenez Milani; Antonio Sérgio Dacome; Silvio Claudio da Costa; Paulo Cezar de Freitas Mathias; Cecília Edna Mareze-Costa
Journal:  Int J Endocrinol       Date:  2018-04-29       Impact factor: 3.257
  5 in total

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