Literature DB >> 16943240

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis.

Ilona Kryczek1, Shuang Wei, Evan Keller, Rebecca Liu, Weiping Zou.   

Abstract

The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and contributes to immunosuppressive networks within the tumor microenvironment. Therefore, it stands to reason that the CXCL12/CXCR4 pathway is an important target for the development of novel anti-cancer therapies. In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed.

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Year:  2006        PMID： 16943240     DOI： 10.1152/ajpcell.00406.2006

Source DB:  PubMed          Journal:  Am J Physiol Cell Physiol        ISSN： 0363-6143            Impact factor:   4.249


  122 in total

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2.  Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation.

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7.  Clinicopathological and prognostic significance of chemokine receptor CXCR4 overexpression in patients with esophageal cancer: a meta-analysis.

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Review 9.  The critical role of SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis.

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