| Literature DB >> 16942884 |
Masanori Miura1, Norio Seki, Takanori Koike, Tsukasa Ishihara, Tatsuya Niimi, Fukushi Hirayama, Takeshi Shigenaga, Yumiko Sakai-Moritani, Tomihisa Kawasaki, Shuichi Sakamoto, Minoru Okada, Mitsuaki Ohta, Shin-ichi Tsukamoto.
Abstract
Inhibition of tissue factor/factor VIIa complex (TF/FVIIa) is an attractive strategy for antithrombotic therapies. We began with an investigation of a non-amidine TF/FVIIa inhibitor based on a modification of amidine compound 1. Optimization of the substituents on the P1 phenyl portion of the compound 1 led to a neutral or less basic alternative for the 4-amidinophenyl moiety. By further optimization of the substituents on the central phenyl ring, a highly potent and selective TF/FVIIa inhibitor 17d was discovered.Entities:
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Year: 2006 PMID： 16942884 DOI： 10.1016/j.bmc.2006.08.010
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641