Literature DB >> 16942013

Synthesis, characterization, and biological evaluation of M(I)(CO)3(NNO) complexes (M = Re, 99mTc) conjugated to 2-(4-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals.

Stamatia Tzanopoulou1, Ioannis C Pirmettis, George Patsis, Maria Paravatou-Petsotas, Evangelia Livaniou, Minas Papadopoulos, Maria Pelecanou.   

Abstract

The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer.

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Year:  2006        PMID： 16942013     DOI： 10.1021/jm0606387

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Characterization of the 4-(benzothiazol-2-yl)phenylnitrenium ion from a putative metabolite of a model antitumor drug.

Authors:  Mrinal Chakraborty; Kyoung Joo Jin; Stephen A Glover; Michael Novak
Journal:  J Org Chem       Date:  2010-08-06       Impact factor: 4.354

2.  NH NMR shifts of new structurally characterized fac-[Re(CO)3(polyamine)]n+ complexes probed via outer-sphere hydrogen-bonding interactions to anions, including the paramagnetic [Re(IV)Br6]2- anion.

Authors:  Theshini Perera; Patricia A Marzilli; Frank R Fronczek; Luigi G Marzilli
Journal:  Inorg Chem       Date:  2010-06-21       Impact factor: 5.165

3.  Insights into the value of statistical models, solvent, and relativistic effects for investigating Re complexes of 2-(4'-aminophenyl)benzothiazole: a potential spectroscopic probe.

Authors:  Gustavo A Andolpho; Elaine F F da Cunha; Teodorico C Ramalho
Journal:  J Mol Model       Date:  2022-05-17       Impact factor: 1.810

4.  Indirect and direct detection of the 4-(benzothiazol-2-yl)phenylnitrenium ion from a putative metabolite of a model anti-tumor drug.

Authors:  Mrinal Chakraborty; Kyoung Joo Jin; Samuel C Brewer; Huo-Lei Peng; Matthew S Platz; Michael Novak
Journal:  Org Lett       Date:  2009-11-05       Impact factor: 6.005

5.  2-(4'-Aminophenyl)benzothiazole Labeled with 99mTc-Cyclopentadienyl for Imaging β-Amyloid Plaques.

Authors:  Christos Kiritsis; Barbara Mavroidi; Antonio Shegani; Lazaros Palamaris; George Loudos; Marina Sagnou; Ioannis Pirmettis; Minas Papadopoulos; Maria Pelecanou
Journal:  ACS Med Chem Lett       Date:  2017-09-18       Impact factor: 4.345

6.  Chemistry of ring-substituted 4-(benzothiazol-2-yl)phenylnitrenium ions from antitumor 2-(4-aminophenyl)benzothiazoles.

Authors:  Yang Zhang; Mrinal Chakraborty; Christian G Cerda-Smith; Ryan N Bratton; Natalie E Maurer; Ethan M Senser; Michael Novak
Journal:  J Org Chem       Date:  2013-07-01       Impact factor: 4.354
  6 in total

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