| Literature DB >> 16941349 |
Erica L T van den Akker1, Jan L Nouwen, Damian C Melles, Elisabeth F C van Rossum, Jan W Koper, André G Uitterlinden, Albert Hofman, Henri A Verbrugh, Huibert A Pols, Steven W J Lamberts, Alex van Belkum.
Abstract
The aim of this study was to determine whether polymorphisms of the glucocorticoid receptor gene, influencing glucocorticoid sensitivity, are associated with persistent nasal carriage of Staphylococcus aureus. Two nasal swab cultures were obtained from each of 2,929 participants. Subjects were classified as persistent carriers (n=563) if both cultures were positive. GG homozygotes of the exon 9beta polymorphism were associated with a 68% reduced risk of persistent S. aureus nasal carriage, whereas carriers of the codon 23 lysine allele displayed an 80% increased risk. Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization.Entities:
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Year: 2006 PMID： 16941349 DOI： 10.1086/506367
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226