Literature DB >> 1694073

The promoter of the proliferating cell nuclear antigen (PCNA) gene is active in serum-derived cells.

L Ottavio1, C D Chang, M G Rizzo, S Petralia, S Travali, R Baserga.   

Abstract

mRNA levels for the Proliferating Cell Nuclear Antigen (PCNA) gene are growth regulated. PCNA promoters of different lengths were used to drive a linked reporter, the cDNA for human thymidine kinase (TK). After transfection into TK ts13 cells, stable cell lines were obtained. Regardless of promoter length, in all cell lines the levels of TK mRNA were roughly similar in serum-deprived and serum stimulated cells, confirming, by an independent method, that the growth regulation of PCNA mRNA levels doe not depend on the 5' flanking sequence of the PCNA gene.

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Year:  1990        PMID： 1694073     DOI： 10.1016/0006-291x(90)90360-y

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  The role of the promoter in the expression of the PCNA gene.

Authors:  R H Charollais; H Alder; A Ferber; J Koniecki; C Sell; R Baserga
Journal:  Gene Expr       Date:  1992

2.  A conserved region in intron 1 negatively regulates the expression of the PCNA gene.

Authors:  H Alder; M Yoshinouchi; M B Prystowsky; P Appasamy; R Baserga
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

3.  Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

Authors:  D Huang; P M Shipman-Appasamy; D J Orten; S H Hinrichs; M B Prystowsky
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272
  3 in total

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