| Literature DB >> 16940073 |
Oscar Cirioni1, Andrea Giacometti, Carmela Silvestri, Agnese Della Vittoria, Alberto Licci, Alessandra Riva, Giorgio Scalise.
Abstract
The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 microM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams.Entities:
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Year: 2006 PMID: 16940073 PMCID: PMC1635209 DOI: 10.1128/AAC.00652-06
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191