Literature DB >> 1693926

Human squamous cell carcinoma from skin: establishment and characterization of a new cell line (HSC-5).

Y Hozumi1, S Kondo, T Shimoura, K Aso.   

Abstract

A new cell line, designated as HSC-5 and derived from human skin squamous cell carcinoma (SCC), has been established in vitro and maintained proliferative in continuous tissue culture for over two years. The cells grow in a monolayer in vitro and have anaplastic epithelioid features. The doubling time was about 35 hr at the 30th passage. Chromosome analysis showed hypotetraploidy with a modal number of 76. A trial of transplantation of the cultured cells into nude mice was not successful. Analysis of cytokeratins from HSC-5 by two-dimensional gel electrophoresis revealed polypeptides No. 5, 8, 13, 18 and 19. The cell line is available to other investigators.

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Year:  1990        PMID： 1693926     DOI： 10.1111/j.1346-8138.1990.tb01615.x

Source DB:  PubMed          Journal:  J Dermatol        ISSN： 0385-2407            Impact factor:   4.005


  7 in total

1.  Keratin specificity analyses of eight anti-keratin monoclonal antibodies, and their immunostaining patterns in normal skin using formalin-fixed and paraffin-embedded tissue specimens.

Authors:  S I Ansai; Y Katagata; K I Yoshikawa; Y Hozumi; K Aso
Journal:  Arch Dermatol Res       Date:  1993       Impact factor: 3.017

2.  Downregulation of keratins 8, 18 and 19 influences invasiveness of human cultured squamous cell carcinoma and adenocarcinoma cells.

Authors:  A Uchiumi; M Yamashita; Y Katagata
Journal:  Exp Ther Med       Date:  2011-12-09       Impact factor: 2.447

Review 3.  Investigating Cutaneous Squamous Cell Carcinoma in vitro and in vivo: Novel 3D Tools and Animal Models.

Authors:  Marika Quadri; Alessandra Marconi; Simran K Sandhu; Alexi Kiss; Tatiana Efimova; Elisabetta Palazzo
Journal:  Front Med (Lausanne)       Date:  2022-05-09

4.  Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial-mesenchymal transition of cancer cells.

Authors:  C R I Lam; C Tan; Z Teo; C Y Tay; T Phua; Y L Wu; P Q Cai; L P Tan; X Chen; P Zhu; N S Tan
Journal:  Cell Death Dis       Date:  2013-10-10       Impact factor: 8.469

5.  Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma.

Authors:  Akiko Kanzaki; Mitsuhiro Kudo; Shin-Ichi Ansai; Wei-Xia Peng; Kousuke Ishino; Tetsushi Yamamoto; Ryuichi Wada; Takenori Fujii; Kiyoshi Teduka; Kiyoko Kawahara; Yoko Kawamoto; Taeko Kitamura; Seiji Kawana; Hidehisa Saeki; Zenya Naito
Journal:  Int J Oncol       Date:  2016-01-05       Impact factor: 5.650

6.  Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway.

Authors:  Pazhanichamy Kalailingam; Hui Bing Tan; Jiun Yit Pan; Suat Hoon Tan; Thirumaran Thanabalu
Journal:  Cells       Date:  2019-02-02       Impact factor: 6.600

7.  N-WASP Attenuates Cell Proliferation and Migration through ERK2-Dependent Enhanced Expression of TXNIP.

Authors:  Yat Joong Chung; Amrita Salvi; Pazhanichamy Kalailingam; Myra Alnawaz; Suat Hoon Tan; Jiun Yit Pan; Nguan Soon Tan; Thirumaran Thanabalu
Journal:  Biology (Basel)       Date:  2022-04-11
  7 in total

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