Literature DB >> 1693903

The prooxidant-induced and spontaneous mitochondrial calcium release: inhibition by meta-iodo-benzylguanidine (MIBG), a substrate for mono (ADP-ribosylation).

C Richter1.   

Abstract

The norepinephrine analogue meta-iodo-benzylguanidine (MIBG), a substrate for mono(ADP-ribosylation) and inhibitor of eukaryotic ADP-ribosyltransferases, inhibits the prooxidant-induced and spontaneous calcium release from intact rat liver mitochondria without affecting pyridine nucleotide oxidation and hydrolysis. This finding strongly suggests regulation of calcium release by ADP-ribosylation in mitochondria, and may be relevant for the cellular and pharmacological effects of MIBG.

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Year:  1990        PMID： 1693903     DOI： 10.3109/10715769009053366

Source DB:  PubMed          Journal:  Free Radic Res Commun        ISSN： 8755-0199


  4 in total

1.  Inhibition of pro-oxidant-induced mitochondrial pyridine nucleotide hydrolysis and calcium release by 4-hydroxynonenal.

Authors:  C Richter; P Meier
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

2.  Fluorodeoxyglucose cell incorporation as an index of cell proliferation: evaluation of accuracy in cell culture.

Authors:  D O Slosman; N Pittet; A Donath; B S Polla
Journal:  Eur J Nucl Med       Date:  1993-11

3.  'Pore' formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria.

Authors:  J Schlegel; M Schweizer; C Richter
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

4.  Hydrogen peroxide induced reproductive and interphase death in two strains of L5178Y murine lymphoma differing in radiation sensitivity.

Authors:  E Bouzyk; I Buraczewska; O Rosiek; B Sochanowicz; I Szumiel
Journal:  Radiat Environ Biophys       Date:  1991       Impact factor: 1.925
  4 in total

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