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Literature DB >> 16938839

Amplification of enantiomeric concentrations under credible prebiotic conditions.

Abstract

Solutions with as little as 1% enantiomeric excess (ee) of D- or L-phenylalanine are amplified to 90% ee (a 95/5 ratio) by two successive evaporations to precipitate the racemate. Such a process on the prebiotic earth could lead to a mechanism by which meteoritic chiral alpha-alkyl amino acids could form solutions with high ee values that were needed for the beginning of biology.

Entities: Chemical

Mesh：

Substances：
Solutions
Phenylalanine

Year: 2006 PMID： 16938839 PMCID： PMC1559738 DOI： 10.1073/pnas.0605863103

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

3 in total

1. Thermodynamic control of asymmetric amplification in amino acid catalysis.

Authors: Martin Klussmann; Hiroshi Iwamura; Suju P Mathew; David H Wells; Urvish Pandya; Alan Armstrong; Donna G Blackmond
Journal: Nature Date: 2006-06-01 Impact factor: 49.962

2. Effect of molecular chirality on racemate stability: alpha-amino acids with nonpolar R groups.

Authors: Jun Huang; Lian Yu
Journal: J Am Chem Soc Date: 2006-02-15 Impact factor: 15.419

Review 3. The chemistry of life's origin: a carbonaceous meteorite perspective.

Authors: Sandra Pizzarello
Journal: Acc Chem Res Date: 2006-04 Impact factor: 22.384

3 in total

24 in total

1. The origin of biological homochirality.

Authors: Donna G Blackmond
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2011-10-27 Impact factor: 6.237

Review 2. The origin of biological homochirality.

Authors: Donna G Blackmond
Journal: Cold Spring Harb Perspect Biol Date: 2010-03-31 Impact factor: 10.005

3. Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation.

Authors: Raffaele Saladino; Eleonora Carota; Giorgia Botta; Mikhail Kapralov; Gennady N Timoshenko; Alexei Y Rozanov; Eugene Krasavin; Ernesto Di Mauro
Journal: Proc Natl Acad Sci U S A Date: 2015-04-13 Impact factor: 11.205

10. Generation of absolute controlled crystal chirality by the removal of crystal water from achiral crystal of nucleobase cytosine.

Authors: Tsuneomi Kawasaki; Yuko Hakoda; Hiroko Mineki; Kenta Suzuki; Kenso Soai
Journal: J Am Chem Soc Date: 2010-03-10 Impact factor: 15.419

Amplification of enantiomeric concentrations under credible prebiotic conditions.

1. Thermodynamic control of asymmetric amplification in amino acid catalysis.

2. Effect of molecular chirality on racemate stability: alpha-amino acids with nonpolar R groups.

Review 3. The chemistry of life's origin: a carbonaceous meteorite perspective.

1. The origin of biological homochirality.

Review 2. The origin of biological homochirality.

3. Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation.

4. Question 4: basic questions about the origin of life: on chirobiogenesis.

5. On the origin of terrestrial homochirality for nucleosides and amino acids.

6. A route to enantiopure RNA precursors from nearly racemic starting materials.

Review 7. The Origin of Biological Homochirality.

8. S-Isovaline Contained in Meteorites, Induces Enantiomeric Excess in D,L-glutamic Acid During Recrystallization.

9. Identifying molecules as biosignatures with assembly theory and mass spectrometry.

10. Generation of absolute controlled crystal chirality by the removal of crystal water from achiral crystal of nucleobase cytosine.