Literature DB >> 16938540

Endogenous TLR ligands and autoimmunity.

Hermann Wagner1.   

Abstract

Based on an evolutionary conserved repertoire Toll-like-receptors (TLRs) donate specificity to innate immune cells. Therefore, TLRs are considered as paradigmatic for "self" versus "non-self" discrimination. This view, however, needs to be modified since TLR's also appear to recognise "endogeneous", that is host-derived ligands, examples being host-derived DNA and -RNA. Here I discuss physiological and pathophysiological consequences of endogeneous ligand-recognition by TLRs. I conclude that endogeneous ligand recognition by TLRs drives sterile inflammation sustained by innate immune cells in certain autoimmune disorders.

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Year:  2006        PMID： 16938540     DOI： 10.1016/S0065-2776(06)91004-9

Source DB:  PubMed          Journal:  Adv Immunol        ISSN： 0065-2776            Impact factor:   3.543


  40 in total

1.  TLR2 activation inhibits embryonic neural progenitor cell proliferation.

Authors:  Eitan Okun; Kathleen J Griffioen; Tae Gen Son; Jong-Hwan Lee; Nicholas J Roberts; Mohamed R Mughal; Emmette Hutchison; Aiwu Cheng; Thiruma V Arumugam; Justin D Lathia; Henriette van Praag; Mark P Mattson
Journal:  J Neurochem       Date:  2010-04-29       Impact factor: 5.372

2.  UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.

Authors:  Reed Pifer; Alicia Benson; Carolyn R Sturge; Felix Yarovinsky
Journal:  J Biol Chem       Date:  2010-11-19       Impact factor: 5.157

3.  Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.

Authors:  Thomas B Thornley; Nancy E Phillips; Britte C Beaudette-Zlatanova; Thomas G Markees; Kapil Bahl; Michael A Brehm; Leonard D Shultz; Evelyn A Kurt-Jones; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Journal:  J Immunol       Date:  2007-11-15       Impact factor: 5.422

Review 4.  TLR8: an innate immune receptor in brain, neurons and axons.

Authors:  Yinghua Ma; Robin L Haynes; Richard L Sidman; Timothy Vartanian
Journal:  Cell Cycle       Date:  2007-09-04       Impact factor: 4.534

Review 5.  The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus.

Authors:  Venu Gopal Jonnalagadda; Allam Venkata Sita Ram Raju; Srinivas Pittala; Afsar Shaik; Nilakash Annaji Selkar
Journal:  Adv Pharm Bull       Date:  2014-02-07

6.  The expression of Toll-like receptors 2, 4 and 9 in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Authors:  H Wang; S-J Gou; M-H Zhao; M Chen
Journal:  Clin Exp Immunol       Date:  2014-09       Impact factor: 4.330

7.  Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.

Authors:  Nicholas A Young; Lai-Chu Wu; Craig J Burd; Alexandra K Friedman; Benjamin H Kaffenberger; Murugesan V S Rajaram; Larry S Schlesinger; Hayley James; Margaret A Shupnik; Wael N Jarjour
Journal:  Clin Immunol       Date:  2014-01-24       Impact factor: 3.969

Review 8.  Toll-like receptor signaling in cell proliferation and survival.

Authors:  Xinyan Li; Song Jiang; Richard I Tapping
Journal:  Cytokine       Date:  2009-09-22       Impact factor: 3.861

9.  Investigation of Toll-like receptors in the pathogenesis of fibrotic and granulomatous disorders: a bronchoalveolar lavage study.

Authors:  Giorgos A Margaritopoulos; Katerina M Antoniou; Kostas Karagiannis; Katerina D Samara; Ismini Lasithiotaki; Evi Vassalou; Rena Lymbouridou; Helen Koutala; Nikos M Siafakas
Journal:  Fibrogenesis Tissue Repair       Date:  2010-10-11

10.  Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects.

Authors:  Mohan R Dasu; Sridevi Devaraj; Samuel Park; Ishwarlal Jialal
Journal:  Diabetes Care       Date:  2010-01-12       Impact factor: 17.152
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