Toxicological review of male reproductive effects and trichloroethylene exposure: assessing the relevance to human male reproductive health.

Effects of trichloroethylene (TCE) on male reproduction and fertility have been studied in mice and rats, and assessed in workers exposed to TCE. Only limited evidence exists for any male reproductive effects in rats or humans. The human studies of TCE male reproductive effects failed to provide much useful information for risk assessment. First, the TCE-specific studies are limited in group size, scope, and typically provide no data on dose, so dose-response assessment is impossible. In other studies, TCE is only one of many solvents identified in the workplace, such that the confounding exposures or lack of evidence of specific exposures make the exposure assessment useless. For TCE risk assessment, one currently must rely upon animal studies as more reliable and useful. The rat studies were generally negative, showing systemic toxicity but little or no male reproductive toxicity. The mouse studies showed various organ effects in the male reproductive system and were typically associated with increased liver weight and kidney toxicity. Enzyme induction and oxidative metabolism appear to be important in the systemic toxicity and may likewise play a role in the reproductive toxicity of TCE. Oxidative metabolites of TCE are formed in the mouse epididymis resulting in epididymal damage, and at systemically toxic high doses, TCE may adversely affect the maturation of sperm and decreasing sperm motility. Protection against systemic toxicity should also protect against adverse effects including male reproductive toxicity.