Literature DB >> 16937517

Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue.

Mustafa Comert, Yucel Ustundag, Ishak Ozel Tekin, Banu Dogan Gun, Figen Barut.   

Abstract

Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16937517      PMCID： PMC4087424          DOI： 10.3748/wjg.v12.i31.5094

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  7 in total

1.  Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis.

Authors:  W Schneiderhan; A Schmid-Kotsas; J Zhao; A Grünert; A Nüssler; H Weidenbach; A Menke; R M Schmid; G Adler; M G Bachem
Journal:  Hepatology       Date:  2001-10       Impact factor: 17.425

2.  Susceptibility to lipopolysaccharide of cholestatic rat liver produced with bile duct ligation: assessments of the mitochondrial glutathione pool and the effects of N-acetylcysteine.

Authors:  H Nakano; Y Fujiwara; N Kitamura; K Kumada; A Matsumiya; H Sakai; T Hatakeyama; M Yamaguchi; D Jaeck
Journal:  Eur Surg Res       Date:  2000       Impact factor: 1.745

3.  Protective effect of melatonin against oxidative stress induced by ligature of extra-hepatic biliary duct in rats: comparison with the effect of S-adenosyl-L-methionine.

Authors:  P M López; I T Fiñana; M C De Agueda; E C Sánchez; M C Muñoz; J P Alvarez; E J De La Torre Lozano
Journal:  J Pineal Res       Date:  2000-04       Impact factor: 13.007

4.  Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.

Authors:  H Y Hsu; S L Chiu; M H Wen; K Y Chen; K F Hua
Journal:  J Biol Chem       Date:  2001-06-04       Impact factor: 5.157

5.  Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading.

Authors:  Y Feng; G F Schreiner; S Chakravarty; D Y Liu; A H Joly
Journal:  Atherosclerosis       Date:  2001-10       Impact factor: 5.162

6.  Cholesteryl esters from oxidized low-density lipoproteins are in vivo rapidly hydrolyzed in rat Kupffer cells and transported to liver parenchymal cells and bile.

Authors:  M N Pieters; S Esbach; D Schouten; A Brouwer; D L Knook; T J Van Berkel
Journal:  Hepatology       Date:  1994-06       Impact factor: 17.425

7.  Experimental bile-duct ligation resulted in accumulation of oxidized low-density lipoproteins in BALB/c mice liver.

Authors:  Mustafa Cömert; Ishak Ozel Tekin; Serefden Acikgöz; Yücel Ustündağ; Bulent H Uçan; Zeki Acun; Figen Barut; Vildan Sümbüloğlu
Journal:  J Gastroenterol Hepatol       Date:  2004-09       Impact factor: 4.029
  7 in total
  1 in total

1.  Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism.

Authors:  Rui-Ping Zhang; Xi-Ping Zhang; Yue-Fang Ruan; Shu-Yun Ye; Hong-Chan Zhao; Qi-Hui Cheng; Di-Jiong Wu
Journal:  World J Gastroenterol       Date:  2009-06-21       Impact factor: 5.742
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.