Literature DB >> 16935744

R&D technology investments: misguided and expensive or a better way to discover medicines?

Esther F Schmid1, Dennis A Smith.   

Abstract

The pharmaceutical industry is in crisis owing to spiralling costs and a lack of new product launches. It is said that expensive investments in technology have not paid off. But is this really true? In this review, we explore some of the recent medicines that were, or are being, brought to market, and we discuss how they were discovered and what difference new technologies have made during the discovery of these medicines.

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Year:  2006        PMID: 16935744     DOI: 10.1016/j.drudis.2006.07.007

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  6 in total

Review 1.  Integrated pharmacokinetics and pharmacodynamics in drug development.

Authors:  Jasper Dingemanse; Silke Appel-Dingemanse
Journal:  Clin Pharmacokinet       Date:  2007       Impact factor: 6.447

2.  Has discovery-based cancer research been a bust?

Authors:  R J Epstein
Journal:  Clin Transl Oncol       Date:  2013-09-04       Impact factor: 3.405

3.  New perspectives on chinese herbal medicine (zhong-yao) research and development.

Authors:  Si-Yuan Pan; Si-Bao Chen; Hong-Guang Dong; Zhi-Ling Yu; Ji-Cui Dong; Zhi-Xian Long; Wang-Fun Fong; Yi-Fan Han; Kam-Ming Ko
Journal:  Evid Based Complement Alternat Med       Date:  2011-03-10       Impact factor: 2.629

Review 4.  Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.

Authors:  Andrew M Beekman; Lesley A Howell
Journal:  ChemMedChem       Date:  2015-12-23       Impact factor: 3.466

5.  Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).

Authors:  Andrew M Beekman; Maria A O'Connell; Lesley A Howell
Journal:  ChemMedChem       Date:  2015-11-30       Impact factor: 3.466

Review 6.  SWOT analysis and revelation in traditional Chinese medicine internationalization.

Authors:  Haitao Tang; Wenlong Huang; Jimei Ma; Li Liu
Journal:  Chin Med       Date:  2018-01-25       Impact factor: 5.455

  6 in total

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