PURPOSE: To examine influences of gestational age and birth parameters on peripapillary nerve fiber layer (NFL) and macular thickness at age six. DESIGN: Cross-sectional study. METHODS: The Sydney Childhood Eye Study examined a random-cluster sample of 1765 six-year-old Sydney school children. Peripapillary NFL and macular thickness were measured (StratusOCT, Zeiss, Dublin, California, USA). Birth parameters were extracted from health records. Multivariate analyses were performed. RESULTS: Higher birth weight children had greater peripapillary NFL, inner and outer (all P(trend) < 0.03), but not central or average macular thickness (both P(trend) > 0.1). Peripapillary NFL (P(trend) = 0.001), inner (P(trend) = 0.01), outer (P(trend) = 0.002), and average macular thickness (P(trend) = 0.02), but not central macular thickness (P(trend) = 0.5) was greater in children with larger head circumference at birth. The central macula was thicker in prematurely (<37 weeks) born children (195.0 microm) than those born at term (191.2 microm), P = 0.04. CONCLUSION: Birth weight and head circumference predicted peripapillary NFL and macular thickness. Prematurity was weakly associated with central macular thickness.
PURPOSE: To examine influences of gestational age and birth parameters on peripapillary nerve fiber layer (NFL) and macular thickness at age six. DESIGN: Cross-sectional study. METHODS: The Sydney Childhood Eye Study examined a random-cluster sample of 1765 six-year-old Sydney school children. Peripapillary NFL and macular thickness were measured (StratusOCT, Zeiss, Dublin, California, USA). Birth parameters were extracted from health records. Multivariate analyses were performed. RESULTS: Higher birth weight children had greater peripapillary NFL, inner and outer (all P(trend) < 0.03), but not central or average macular thickness (both P(trend) > 0.1). Peripapillary NFL (P(trend) = 0.001), inner (P(trend) = 0.01), outer (P(trend) = 0.002), and average macular thickness (P(trend) = 0.02), but not central macular thickness (P(trend) = 0.5) was greater in children with larger head circumference at birth. The central macula was thicker in prematurely (<37 weeks) born children (195.0 microm) than those born at term (191.2 microm), P = 0.04. CONCLUSION: Birth weight and head circumference predicted peripapillary NFL and macular thickness. Prematurity was weakly associated with central macular thickness.
Authors: Adam L Rothman; Monica B Sevilla; Sharon F Freedman; Amy Y Tong; Vincent Tai; Du Tran-Viet; Sina Farsiu; Cynthia A Toth; Mays A El-Dairi Journal: Am J Ophthalmol Date: 2015-01-26 Impact factor: 5.258
Authors: Adam L Rothman; Monica B Sevilla; Shwetha Mangalesh; Kathryn E Gustafson; Laura Edwards; C Michael Cotten; Joshua S Shimony; Carolyn E Pizoli; Mays A El-Dairi; Sharon F Freedman; Cynthia A Toth Journal: Am J Ophthalmol Date: 2015-09-18 Impact factor: 5.258
Authors: Amy Y Tong; Mays El-Dairi; Ramiro S Maldonado; Adam L Rothman; Eric L Yuan; Sandra S Stinnett; Laura Kupper; C Michael Cotten; Kathryn E Gustafson; Ricki F Goldstein; Sharon F Freedman; Cynthia A Toth Journal: Ophthalmology Date: 2014-05-06 Impact factor: 12.079
Authors: Kathleen I C Dyer; Paul G Sanfilippo; Seyhan Yazar; Jamie E Craig; Alex W Hewitt; John P Newnham; David A Mackey; Samantha S Y Lee Journal: Transl Vis Sci Technol Date: 2022-07-08 Impact factor: 3.048
Authors: Liangbo L Shen; Shwetha Mangalesh; Brendan McGeehan; Vincent Tai; Neeru Sarin; Mays A El-Dairi; Sharon F Freedman; Maureen G Maguire; Cynthia A Toth Journal: Am J Ophthalmol Date: 2020-09-04 Impact factor: 5.258