Literature DB >> 16935213

Squalamine lactate for exudative age-related macular degeneration.

Brian Connolly1, Avinash Desai, Charles A Garcia, Edgar Thomas, Michael J Gast.   

Abstract

Squalamine lactate inhibits angiogenesis by a long-lived, intracellular mechanism of action. The drug is taken up into activated endothelial cells through caveolae, small invaginations in the cellular membrane. Subsequently, the drug binds to and "chaperones" calmodulin to an intracellular membrane compartment and blocks angiogenesis at several levels. A series of basic investigations, preclinical studies, and human clinical trials have begun to establish the proof of concept, efficacy, and safety parameters for use of squalamine lactate as a therapeutic agent for exudative age-related macular degeneration and several types of malignancies.

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Year:  2006        PMID： 16935213     DOI： 10.1016/j.ohc.2006.05.003

Source DB:  PubMed          Journal:  Ophthalmol Clin North Am        ISSN： 0896-1549


  8 in total

1.  Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential.

Authors:  Michael Zasloff; A Paige Adams; Bernard Beckerman; Ann Campbell; Ziying Han; Erik Luijten; Isaura Meza; Justin Julander; Abhijit Mishra; Wei Qu; John M Taylor; Scott C Weaver; Gerard C L Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

2.  Recent advances in the treatment of age-related macular degeneration.

Authors:  Ameenat Lola Solebo; Romesh I Angunawela; Samipa Dasgupta; John Marshall
Journal:  Br J Gen Pract       Date:  2008-05       Impact factor: 5.386

3.  Substituted oxines inhibit endothelial cell proliferation and angiogenesis.

Authors:  Shridhar Bhat; Joong Sup Shim; Feiran Zhang; Curtis Robert Chong; Jun O Liu
Journal:  Org Biomol Chem       Date:  2012-03-06       Impact factor: 3.876

4.  Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression.

Authors:  Diana C Márquez-Garbán; Manuel Gorrín-Rivas; Hsiao-Wang Chen; Colin Sterling; David Elashoff; Nalo Hamilton; Richard J Pietras
Journal:  Cancer Lett       Date:  2019-02-13       Impact factor: 8.679

Review 5.  Squalamine and Its Aminosterol Derivatives: Overview of Biological Effects and Mechanisms of Action of Compounds with Multiple Therapeutic Applications.

Authors:  Nour Mammari; Elsa Salles; Audrey Beaussart; Sofiane El-Kirat-Chatel; Mihayl Varbanov
Journal:  Microorganisms       Date:  2022-06-13

Review 6.  Recent advances in the management and understanding of macular degeneration.

Authors:  Sepehr Bahadorani; Michael Singer
Journal:  F1000Res       Date:  2017-04-20

7.  A Potential Antineoplastic Peptide of Human Prostate Cancer Cells Derived from the Lesser Spotted Dogfish (Scyliorhinus canicula L.).

Authors:  Adrien Bosseboeuf; Amandine Baron; Elise Duval; Aude Gautier; Pascal Sourdaine; Pierrick Auvray
Journal:  Mar Drugs       Date:  2019-10-16       Impact factor: 5.118

8.  K092A and K092B, Two Peptides Isolated from the Dogfish (Scyliorhinus canicula L.), with Potential Antineoplastic Activity Against Human Prostate and Breast Cancer Cells.

Authors:  Adrien Bosseboeuf; Amandine Baron; Elise Duval; Aude Gautier; Pascal Sourdaine; Pierrick Auvray
Journal:  Mar Drugs       Date:  2019-11-28       Impact factor: 5.118
  8 in total

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