OBJECTIVE: The aim of this study was to determine heritability estimates for dental caries traits and sucrose sweetness preference. DESIGN: Participants included 115 pairs of twins 4-7-years-old. Caries exams followed NIDCR criteria where the severity of the lesion was also determined. Twins ranked their preference for five concentrations of sucrose/grape juice solutions (0.15-1.17M) with a Face Scale. Variables submitted to analysis: (1) surface-based caries prevalence rate (SBCPR); (2) lesion severity index (LSI); (3) sucrose sweetness preference score (SSPS). Heritability analyses were performed with the SOLAR software package. RESULTS: Heritability estimates adjusted for age and gender were: SBCPR-h(2)=64.6 (p<.00001), LSI-h(2)=61.7 (p<.00001) and SSPS-h(2)=55.2 (p<.00001). Treating SPSS as a covariate in the SBCPR and LSI models did not alter heritability estimates. CONCLUSIONS: These results suggest that variation in dental caries traits and sucrose sweetness preference have a significant genetic contribution that is mediated independently.
OBJECTIVE: The aim of this study was to determine heritability estimates for dental caries traits and sucrose sweetness preference. DESIGN:Participants included 115 pairs of twins 4-7-years-old. Caries exams followed NIDCR criteria where the severity of the lesion was also determined. Twins ranked their preference for five concentrations of sucrose/grape juice solutions (0.15-1.17M) with a Face Scale. Variables submitted to analysis: (1) surface-based caries prevalence rate (SBCPR); (2) lesion severity index (LSI); (3) sucrose sweetness preference score (SSPS). Heritability analyses were performed with the SOLAR software package. RESULTS: Heritability estimates adjusted for age and gender were: SBCPR-h(2)=64.6 (p<.00001), LSI-h(2)=61.7 (p<.00001) and SSPS-h(2)=55.2 (p<.00001). Treating SPSS as a covariate in the SBCPR and LSI models did not alter heritability estimates. CONCLUSIONS: These results suggest that variation in dental caries traits and sucrose sweetness preference have a significant genetic contribution that is mediated independently.
Authors: J R Shaffer; X Wang; R S Desensi; S Wendell; R J Weyant; K T Cuenco; R Crout; D W McNeil; M L Marazita Journal: Caries Res Date: 2012-01-25 Impact factor: 4.056
Authors: S Wendell; X Wang; M Brown; M E Cooper; R S DeSensi; R J Weyant; R Crout; D W McNeil; M L Marazita Journal: J Dent Res Date: 2010-09-21 Impact factor: 6.116
Authors: Jessica Briseño-Ruiz; Takehiko Shimizu; Kathleen Deeley; Piper M Dizak; Timothy D Ruff; Italo M Faraco; Fernando A Poletta; João A Brancher; Giovana D Pecharki; Erika C Küchler; Patricia N Tannure; Andrea Lips; Thays C S Vieira; Asli Patir; Mine Koruyucu; Juan C Mereb; Judith M Resick; Carla A Brandon; Ariadne Letra; Renato M Silva; Margaret E Cooper; Figen Seymen; Marcelo C Costa; José M Granjeiro; Paula C Trevilatto; Iêda M Orioli; Eduardo E Castilla; Mary L Marazita; Alexandre R Vieira Journal: Hum Genet Date: 2013-05-09 Impact factor: 4.132
Authors: X Wang; M C Willing; M L Marazita; S Wendell; J J Warren; B Broffitt; B Smith; T Busch; A C Lidral; S M Levy Journal: Caries Res Date: 2012-04-13 Impact factor: 4.056
Authors: T Shimizu; K Deeley; J Briseño-Ruiz; I M Faraco; F A Poletta; J A Brancher; G D Pecharki; E C Küchler; P N Tannure; A Lips; T C S Vieira; A Patir; M Yildirim; J C Mereb; J M Resick; C A Brandon; M E Cooper; F Seymen; M C Costa; J M Granjeiro; P C Trevilatto; I M Orioli; E E Castilla; M L Marazita; A R Vieira Journal: Caries Res Date: 2013-01-30 Impact factor: 4.056