Literature DB >> 16934457

Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.

Jack J Chen1, Kumar D Thakur, Michael P Clark, Steven K Laughlin, Kelly M George, Roger G Bookland, Jan R Davis, Edward J Cabrera, Vijay Easwaran, Biswanath De, Y George Zhang.   

Abstract

A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK3.

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Year:  2006        PMID: 16934457     DOI: 10.1016/j.bmcl.2006.08.022

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  8 in total

1.  JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules.

Authors:  Ana S Newton; Luca Deiana; David E Puleo; José A Cisneros; Kara J Cutrona; Joseph Schlessinger; William L Jorgensen
Journal:  ACS Med Chem Lett       Date:  2017-05-17       Impact factor: 4.345

2.  Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.

Authors:  Maninder Kaur; Pankaj Kumar Singh; Manjinder Singh; Renu Bahadur; Om Silakari
Journal:  Mol Divers       Date:  2017-11-14       Impact factor: 2.943

3.  Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.

Authors:  Haneesh Jasuja; Navriti Chadha; Maninder Kaur; Om Silakari
Journal:  Mol Divers       Date:  2014-01-11       Impact factor: 2.943

4.  Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.

Authors:  Eric R Goedken; Maria A Argiriadi; David L Banach; Bryan A Fiamengo; Sage E Foley; Kristine E Frank; Jonathan S George; Christopher M Harris; Adrian D Hobson; David C Ihle; Douglas Marcotte; Philip J Merta; Mark E Michalak; Sara E Murdock; Medha J Tomlinson; Jeffrey W Voss
Journal:  J Biol Chem       Date:  2014-12-31       Impact factor: 5.157

5.  Development of Selective Covalent Janus Kinase 3 Inhibitors.

Authors:  Li Tan; Koshi Akahane; Randall McNally; Kathleen M S E Reyskens; Scott B Ficarro; Suhu Liu; Grit S Herter-Sprie; Shohei Koyama; Michael J Pattison; Katherine Labella; Liv Johannessen; Esra A Akbay; Kwok-Kin Wong; David A Frank; Jarrod A Marto; Thomas A Look; J Simon C Arthur; Michael J Eck; Nathanael S Gray
Journal:  J Med Chem       Date:  2015-08-18       Impact factor: 7.446

Review 6.  Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.

Authors:  Claude Haan; Iris Behrmann; Serge Haan
Journal:  J Cell Mol Med       Date:  2010-01-28       Impact factor: 5.310

7.  Kinase inhibitors for the treatment of inflammatory and autoimmune disorders.

Authors:  Shripad S Bhagwat
Journal:  Purinergic Signal       Date:  2008-06-21       Impact factor: 3.765

8.  Pharmacophore and Virtual Screening of JAK3 inhibitors.

Authors:  Murugesan Rajeswari; Natchimuthu Santhi; Vembu Bhuvaneswari
Journal:  Bioinformation       Date:  2014-03-19
  8 in total

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