| Literature DB >> 16934455 |
Shunqi Yan1, Todd Appleby, Gary Larson, Jim Z Wu, Robert Hamatake, Zhi Hong, Nanhua Yao.
Abstract
A structure-based approach was performed to design a novel thiazolone scaffold as HCV NS5B inhibitors. A focused library was designed and docked by GOLD. One of the top-scored molecules was synthesized and shown to have similar potency to the initial hit. The X-ray complex structure was determined and validated our design rationale.Entities:
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Year: 2006 PMID： 16934455 DOI： 10.1016/j.bmcl.2006.08.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823