PURPOSE: TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid hormone and oestrogen receptors. This study investigated the expression of TRAP220 mRNA and protein level in epileptic brains comparing with human control. METHODS: We examined the expression of TRAP220 mRNA and protein levels in temporal lobes from patients with chronic pharmacoresistant epilepsy who have undergone surgery. RESULTS: Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of the patients with epilepsy. CONCLUSIONS: Our work showed that a decrease in TRAP220 mRNA and protein levels may be involved in the pathophysiology of epilepsy and may be associated with impairment of the brain caused by frequent seizures.
PURPOSE:TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid hormone and oestrogen receptors. This study investigated the expression of TRAP220 mRNA and protein level in epileptic brains comparing with human control. METHODS: We examined the expression of TRAP220 mRNA and protein levels in temporal lobes from patients with chronic pharmacoresistant epilepsy who have undergone surgery. RESULTS: Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of the patients with epilepsy. CONCLUSIONS: Our work showed that a decrease in TRAP220 mRNA and protein levels may be involved in the pathophysiology of epilepsy and may be associated with impairment of the brain caused by frequent seizures.
Authors: Zhan-hui Feng; Junwei Hao; Lan Ye; Carlos Dayao; Ning Yan; Yong Yan; Lan Chu; Fu-dong Shi Journal: Seizure Date: 2011-02-10 Impact factor: 3.184
Authors: Ulrich Pfisterer; Viktor Petukhov; Samuel Demharter; Johanna Meichsner; Jonatan J Thompson; Mykhailo Y Batiuk; Andrea Asenjo-Martinez; Navneet A Vasistha; Ashish Thakur; Jens Mikkelsen; Istvan Adorjan; Lars H Pinborg; Tune H Pers; Jakob von Engelhardt; Peter V Kharchenko; Konstantin Khodosevich Journal: Nat Commun Date: 2020-10-07 Impact factor: 14.919