| Literature DB >> 16933867 |
Xinlan Zhou1, Xiangjiu He, Guanghui Wang, Hao Gao, Guangxiong Zhou, Wencai Ye, Xinsheng Yao.
Abstract
Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. All seven compounds were tested for their cytotoxicity using four human tumor cell lines (HepG2, NCI-H460, MCF-7, SF-268). Only compound 1 was cytotoxic, with IC50 values of 0.25-4.49 microM.Entities:
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Year: 2006 PMID： 16933867 DOI： 10.1021/np060091z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050