Literature DB >> 1693349

A cDNA clone encoding a peptide highly specific for hepatitis C infection.

T Arima1, C Mori, A Takamizawa, H Shimomura, T Tsuji.   

Abstract

A random primed lambda gt11-cDNA library was constructed from donors plasma presumably infected by blood-borne non-A, non-B hepatitis (hepatitis C:HC) agent and immunoscreened with serum pooled from patients with acute or chronic HC. Twelve lambda gt11-cDNA clones encoding antigens associated with HC infection in Japan as well as in the USA were isolated. Of these one clone consisting of 114 nucleotides and showing a discrete band on an immunoblot analysis, was extensively studied. The clone is not derived from the host DNA encoding one polypeptide specific and highly sensitive for serum from patients with HC and has no homology to the nucleotide sequences of known human viruses including hepatitis A,B and D viruses, Ebstein-Barr virus, coxsackievirus, immunodeficiency virus type 1 or Japanese encephalitis virus. These results suggest that this clone is derived from the genome of HC agent.

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Year:  1990        PMID： 1693349     DOI： 10.1007/bf02776819

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  13 in total

1.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

Authors:  Q L Choo; G Kuo; A J Weiner; L R Overby; D W Bradley; M Houghton
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

2.  Transfusion-associated hepatitis not due to viral hepatitis type A or B.

Authors:  S M Feinstone; A Z Kapikian; R H Purcell; H J Alter; P V Holland
Journal:  N Engl J Med       Date:  1975-04-10       Impact factor: 91.245

3.  Isolation and functional property of mRNA coding for hepatitis A, B, and non A-non B viral particles from human sera.

Authors:  A A Hakim
Journal:  Naturwissenschaften       Date:  1986-01

Review 4.  Etiology and natural history of post-transfusion and enterically-transmitted non-A, non-B hepatitis.

Authors:  D W Bradley; J E Maynard
Journal:  Semin Liver Dis       Date:  1986-02       Impact factor: 6.115

5.  Removal of RNase activity from DNase by affinity chromatography on agarose coupled aminophenylphosphoryl-uridine-2' (3')-phosphate.

Authors:  I H Maxwell; F Maxwell; W E Hahn
Journal:  Nucleic Acids Res       Date:  1977-01       Impact factor: 16.971

6.  Dideoxy sequencing method using denatured plasmid templates.

Authors:  M Hattori; Y Sakaki
Journal:  Anal Biochem       Date:  1986-02-01       Impact factor: 3.365

7.  Cloning of a cDNA associated with acute and chronic hepatitis C infection generated from patients serum RNA.

Authors:  T Arima; H Nagashima; S Murakami; C Kaji; J Fujita; H Shimomura; T Tsuji
Journal:  Gastroenterol Jpn       Date:  1989-10

8.  A lambda gt11-cDNA clone specific for chronic hepatitis C generated from pooled serum presumably infected by hepatitis C virus.

Authors:  T Arima; A Takamizawa; C Mori; S Murakami; C Kaji; J Fujita
Journal:  Gastroenterol Jpn       Date:  1989-10

Review 9.  Non-A, non-B hepatitis: evolving epidemiologic and clinical perspective.

Authors:  J L Dienstag; H J Alter
Journal:  Semin Liver Dis       Date:  1986-02       Impact factor: 6.115

10.  The agents of non-A, non-B viral hepatitis.

Authors:  D W Bradley
Journal:  J Virol Methods       Date:  1985-04       Impact factor: 2.014
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  2 in total

1.  Development of a specific enzyme-linked immunosorbent assay for the hepatitis C virus antibody using clone 14.

Authors:  M Oketani; H Kawabata; S Imamura; E Maeda; H Tsubouchi; T Arima
Journal:  Gastroenterol Jpn       Date:  1993-02

Review 2.  Hepatitis C: basic and clinical studies.

Authors:  T Arima
Journal:  Gastroenterol Jpn       Date:  1992-02
  2 in total

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