Literature DB >> 1693342

Inhibition of in vitro RNA synthesis by hycanthone, oxamniquine and praziquantel.

L J Wong1, G C Tsao, J I Bruce, S S Wong.   

Abstract

The schistosomicides, hycanthone, oxamniquine and praziquantel, were found to inhibit the in vitro RNA synthesis using isolated hamster liver nuclei. Preincubation of the nuclei with these drugs revealed that the inhibitory effect of oxamniquine was irreversible and progressed with time, whereas that of hycanthone and praziquantel was reversible. On the other hand, hycanthone and praziquantel have a high affinity for DNA but oxamniquine does not. The data indicate that the mechanism of inhibition by oxamniquine is different from that of hycanthone and praziquantel.

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Year:  1990        PMID： 1693342     DOI： 10.1007/bf01954230

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  21 in total

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Authors:  N Katz
Journal:  Adv Pharmacol Chemother       Date:  1977

2.  RNA synthesis in isolated hen oviduct nuclei.

Authors:  M J Ernest; G Schutz; P Feigelson
Journal:  Biochemistry       Date:  1976-02-24       Impact factor: 3.162

3.  Ribosomal RNA synthesis in isolated nuclei.

Authors:  R H Reeder; R G Roeder
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

4.  Transcription of ribonucleic acid in isolated mouse myeloma nuclei.

Authors:  W F Marzluff; E C Murphy; R C Huang
Journal:  Biochemistry       Date:  1973-08-28       Impact factor: 3.162

5.  Rapid binding of PMB to non-SH groups on hemerythrin.

Authors:  M H Klapper
Journal:  Biochem Biophys Res Commun       Date:  1970-01-06       Impact factor: 3.575

Review 6.  The chemotherapy of schistosomiasis.

Authors:  S Archer
Journal:  Annu Rev Pharmacol Toxicol       Date:  1985       Impact factor: 13.820

7.  Serum concentrations and renal excretion in humans after oral administration of praziquantel--results of three determination methods.

Authors:  K Patzschke; J Pütter; L A Wegner; F A Horster; H W Diekmann
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441

8.  High proportion of multi-locus deletions among hycanthone-induced X-linked recessive lethals in Drosophila melanogaster.

Authors:  P G Kramers; A P Schalet; E Paradi; L Huiser-Hoogteyling
Journal:  Mutat Res       Date:  1983-02       Impact factor: 2.433

9.  Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni.

Authors:  R H Fetterer; R A Pax; J L Bennett
Journal:  Eur J Pharmacol       Date:  1980-05-30       Impact factor: 4.432

10.  A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum.

Authors:  R Pax; J L Bennett; R Fetterer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-10       Impact factor: 3.000
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